Results 41 to 50 of about 1,702,166 (311)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Synchronized Full-Field Strain and Temperature Measurements of Commercially Pure Titanium under Tension at Elevated Temperatures and High Strain Rates

open access: yesMetals, 2021
Understanding the mechanical behavior of materials at extreme conditions, such as high temperatures, high strain rates, and very large strains, is fundamental for applications where these conditions are possible. Although tensile testing has been used to
Guilherme Corrêa Soares, Mikko Hokka
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Effect of Expanded Perlite Aggregate Plaster on the Behavior of High-Temperature Reinforced Concrete Structures

open access: yesBuildings, 2023
Polyurethane-based materials, which are widely used in exterior cladding, pose a great risk for buildings because they can easily catch fire at temperatures as low as 50–65 °C.
İsmet Ulusu, Aslıhan Kurnuç Seyhan
doaj   +1 more source

Quasiparticle relaxation in optically excited high-Q superconducting resonators

open access: yes, 2008
The quasiparticle relaxation time in superconducting films has been measured as a function of temperature using the response of the complex conductivity to photon flux.
J. J. A. Baselmans   +6 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Exploring the friction and wear behaviors of Ag-Mo hybrid modified thermosetting polyimide composites at high temperature

open access: yesFriction, 2019
Polyimide composites have been extensively used as motion components under extreme conditions for their thermal stability and special self-lubricating performance.
Chunjian Duan   +9 more
doaj   +1 more source

Structural application of high strength, high temperature ceramics [PDF]

open access: yes, 1982
The operation of rocket engine turbine pumps is limited by the temperature restrictions of metallic components used in the systems. Mechanical strength and stability of these metallic components decrease drastically at elevated temperatures.
Hall, W. B.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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