Results 51 to 60 of about 1,722,339 (362)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Improvement of Strength and Impact Toughness for Cold-Worked Austenitic Stainless Steels Using a Surface-Cracking Technique

Metals, 2018
For cryogenic applications, materials must be cautiously selected because of a drastic degradation in the mechanical properties of materials when they are exposed to very low temperatures.
Kwangyoon Kim, Minha Park, Jaeho Jang, Hyoung Chan Kim, Hyoung-Seok Moon, Dong-Ha Lim, Jong Bae Jeon, Se-Hun Kwon, Hyunmyung Kim, Byung Jun Kim   +9 more
doaj   +1 more source

Zeolitic imidazolate framework as humidity-resistant solid state-chemiresistive gas sensors: A review

Heliyon, 2023
With significant technological advances, solid-state gas sensors have been extensively applied to detect toxic gases and volatile organic compounds (VOCs) in confined areas such as indoor environments and industries and to identify gas leakage ...
Malepe Lesego, Derek T. Ndinteh, Patrick Ndungu, Messai A. Mamo   +3 more
doaj   +1 more source

Structural application of high strength, high temperature ceramics [PDF]

, 1982
The operation of rocket engine turbine pumps is limited by the temperature restrictions of metallic components used in the systems. Mechanical strength and stability of these metallic components decrease drastically at elevated temperatures.
Hall, W. B.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Tungsten material properties at high temperature and high stress

, 2010
This paper has been withdrawn by the author - it has been published ...
Skoro, G. P., Bennett, J. R. J., Edgecock, T. R., Gray, S. A., McFarland, A. J., Booth, C. N.   +5 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

High-temperature tensile strength of C/SiC composite under laser-induced high heating flux in an aerobic environment

Scientific Reports
Based on the advantages of laser high brightness, a high-temperature mechanical property measuring device has been developed, which can measure the high-temperature strength of C/SiC composites under the condition of short-term high-temperature rise rate
Jiawei Wang, Bin Li, Shanshan Wang, Shunlei Zhang, Pengling Yang, Chenghua Wei, Yanlong Shen   +6 more
doaj   +1 more source