Results 51 to 60 of about 6,033,440 (255)

Associations of parental reproductive age and elevated blood pressure in offspring: An observational study

Frontiers in Pediatrics, 2023
BackgroundIncreased parental reproductive age has been a social trend around the world, and elevated blood pressure in children leads to an approximately two-fold increased risk of hypertension in adulthood.
Rui Deng, Ke Lou, Siliang Zhou, Xingxiu Li, Bin Dong, Jun Ma, Jie Hu   +6 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Unplanned cesarean sections in advanced maternal age: A predictive model

Acta Obstetricia et Gynecologica Scandinavica
Introduction As maternal age during pregnancy is rising all over the world, there is a growing need for prognostic factors that determine maternal and perinatal outcomes in older women.
Joyce Veenstra, Zoë Cohen, Fleurisca J. Korteweg, David P. van derHam, Simone M. Kuppens, Janna A. Kroese, Brenda B. Hermsen, Marije M. Kamphuis, Joost W. Vanhommerig, Maria G. vanPampus   +9 more
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Cues of maternal condition influence offspring selfishness [PDF]

, 2014
The evolution of parent-offspring communication was mostly studied from the perspective of parents responding tobegging signals conveying information about offspring condition.
Wong, Janine, Christophe Lucas (222118), Mathias Kölliker, Kölliker, Mathias, Janine W. Y. Wong (517388), Mathias Kölliker (368108), Janine W Y Wong, Wong, Janine W. Y., Lucas, Christophe, Christophe Lucas   +9 more
core   +2 more sources

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

Clinical Study of Cutaneous Manifestations in Neonates in A Tertiary Care Center in Eastern Nepal: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association
Introduction: In the neonatal period, a variety of cutaneous symptoms are frequent. To minimize unneeded therapy and to reduce parents' stress, it's important to distinguish between transient and pathological newborn dermatoses.
Anil Timilsina, Nisha Keshary Bhatta, Nidhi Shah   +2 more
doaj   +1 more source

Disease Spread in Age Structured Populations with Maternal Age Effects

, 2017
Fundamental ecological processes, such as extrinsic mortality, determine population age structure. This influences disease spread when individuals of different ages differ in susceptibility or when maternal age determines offspring susceptibility.
Garbutt, Jennie S., Clark, Jessica, McNally, Luke, Little, Tom J.   +3 more
core   +1 more source

The effect of delaying childbirth on primary cesarean section rates [PDF]

, 2008
<p><b>Background:</b> The relationship between population trends in delaying childbirth and rising rates of primary cesarean delivery is unclear.
Yolande Cordeaux, Fleming Michael, Hannah Missfelder-Lobos, Missfelder-Lobos, Hannah, Jill P Pell, Smith, Gordon C S, Missfelder-Lobos Hannah, Pell, Jill P, Charnock-Jones, D Stephen, Fleming, M., Michael Fleming, Dharmintra Pasupathy, Smith Gordon C. S, White, Ian R, White Ian R, Pasupathy, Dharmintra, Fleming, Michael, Cordeaux Yolande, Gordon C S Smith, White, I.R., Pasupathy, D., Cordeaux, Y., Pell, J., Pasupathy Dharmintra, Charnock-Jones, D.S., Pell Jill P, Smith, G.C.S., Cordeaux, Yolande, D. Stephen Charnock-Jones, Gordon C. S Smith, D Stephen Charnock-Jones, Ian R White, Charnock-Jones D. Stephen, Missfelder-Lobos, M.   +33 more
core   +2 more sources