Impact of Maternal Age on Oocyte and Embryo Competence
Frontiers in Endocrinology, 2018 The overall success of human reproduction, either spontaneously or after IVF, is highly dependent upon maternal age. The main reasons for age-related infertility include reduced ovarian reserve and decreased oocyte/embryo competence due to aging insults,
D. Cimadomo +5 more
semanticscholar +1 more source
Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core +1 more source
Effect of maternal age on the risk of preterm birth: A large cohort study
PLoS ONE, 2018 Background Maternal age at pregnancy is increasing worldwide as well as preterm birth. However, the association between prematurity and advanced maternal age remains controversial.
F. Fuchs +4 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in NeurologyBackgroundPharmacoresistance to conventional antiseizure medications has been described in approximately 30% of the pediatric epileptic patients, making pharmacological management particularly challenging for physicians.
Ambra Butera +11 more
doaj +1 more source
Exploration of the Clinico-Biochemical Parameters to Explain the Altered Renal Mechanisms in Gestational Diabetes Mellitus [PDF]
Journal of Clinical and Diagnostic Research, 2012 Context: Gestational diabetes mellitus (GDM) is a common metabolic abnormality which affects ~2-5% of the pregnancies annually. Various risk factors such as advanced maternal age, previous infants with macrosomia, a strong family history of non ...
Nagalakshmi C.S. +7 more
doaj
Inhibitory control as a mediator of bidirectional effects between early oppositional behavior and maternal depression. [PDF]
, 2014 Maternal depression is an established risk factor for child conduct problems, but relatively few studies have tested whether children's behavioral problems exacerbate mothers' depression or whether other child behavioral characteristics (e.g., self ...
Brennan, Lauretta M +4 more
core +1 more source
Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]
, 2020 Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi +8 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
First-trimester ultrasound diagnosis of sirenomelia: A case report
Case Reports in Women's HealthSirenomelia is a rare congenital malformation characterized by the fusion of the lower limbs and is generally associated with severe multisystem anomalies.
Carla Ettore +5 more
doaj +1 more source