Results 61 to 70 of about 9,803,652 (406)

Efficacy and safety of cannabidiol in a single-center pediatric drug-resistant epilepsy cohort: a retrospective study

open access: yesFrontiers in Neurology
BackgroundPharmacoresistance to conventional antiseizure medications has been described in approximately 30% of the pediatric epileptic patients, making pharmacological management particularly challenging for physicians.
Ambra Butera   +11 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

An Ecological Risk Model for Early Childhood Anxiety: The Importance of Early Child Symptoms and Temperament [PDF]

open access: yes, 2010
Childhood anxiety is impairing and associated with later emotional disorders. Studying risk factors for child anxiety may allow earlier identification of at-risk children for prevention efforts.
Briggs-Gowan, Margaret J.   +3 more
core   +3 more sources

First-trimester ultrasound diagnosis of sirenomelia: A case report

open access: yesCase Reports in Women's Health
Sirenomelia is a rare congenital malformation characterized by the fusion of the lower limbs and is generally associated with severe multisystem anomalies.
Carla Ettore   +5 more
doaj   +1 more source

Associations of parental reproductive age and elevated blood pressure in offspring: An observational study

open access: yesFrontiers in Pediatrics, 2023
BackgroundIncreased parental reproductive age has been a social trend around the world, and elevated blood pressure in children leads to an approximately two-fold increased risk of hypertension in adulthood.
Rui Deng   +6 more
doaj   +1 more source

Association of Maternal Age With Severe Maternal Morbidity and Mortality in Canada

open access: yesJAMA Network Open, 2019
Key Points Question Is maternal age associated with severe maternal morbidity and with maternal death in Canada? Findings In this nationwide population-based cohort study of 3.1 million pregnancies in Canada, severe maternal morbidity has increased over ...
K. Aoyama   +8 more
semanticscholar   +1 more source

Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay in Two Half‐Siblings

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS) is caused by biallelic pathogenic variants in the SACS gene. We report the clinical, radiologic and neurophysiologic features of a pair of half‐siblings who presented with progressive cerebellar ataxia, peripheral neuropathy and upper motor neuron signs.
Dennis Yeow   +6 more
wiley   +1 more source

Exploration of the Clinico-Biochemical Parameters to Explain the Altered Renal Mechanisms in Gestational Diabetes Mellitus [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2012
Context: Gestational diabetes mellitus (GDM) is a common metabolic abnormality which affects ~2-5% of the pregnancies annually. Various risk factors such as advanced maternal age, previous infants with macrosomia, a strong family history of non ...
Nagalakshmi C.S.   +7 more
doaj  

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma   +5 more
wiley   +1 more source

Synchrony, complexity and directiveness in mothers\u27 interactions with infants pre- and post-cochlear implantation [PDF]

open access: yes, 2014
This study investigated effects of profound hearing loss on mother–infant interactions before and after cochlear implantation with a focus on maternal synchrony, complexity, and directiveness.
Bergeson, Tonya R.   +2 more
core   +1 more source

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