Results 81 to 90 of about 470,786 (260)

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Advanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen, Jinsi Chen, Li Huang, Xingqiang Lai, Kai Xia, Qiying Lu, Bingbing Xie, Yinong Huang, Yuan Qiu, Tao Wang, Jianqi Feng, Yuanjun Guan, Siyao Che, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Effect of continuity of team midwifery care on maternal and neonatal outcomes: a quasi-experimental study in Iran

Scientific Reports
Midwife-led continuity of care models have been linked to better clinical outcomes in certain developed countries. However, there is a paucity of research on these models in developing nations.
Sholeh Shahinfar, Parvin Abedi, Mahin Najafian, Zahra Abbaspoor, Eesa Mohammadi, Narges Alianmoghaddam, Elham Maraghi   +6 more
doaj   +1 more source

Coronavirus disease 2019 in pregnancy: clinical manifestations, maternal, and perinatal outcomes

Zanco Journal of Medical Sciences
Background and objective: The current COVID-19 pandemic has become a main health threat worldwide and concerns have been raised regarding the effect of the Covid-19 infection on the wellbeing of pregnant women and their unborn baby.
Asan Nashaat Khaleel, Nagham Younus Alhur   +1 more
doaj   +1 more source

Intrafamily Resource Allocations: A Dynamic Model of Birth Weight [PDF]

This paper estimates a model of dynamic intrahousehold investment behavior which incorporates family fixed effects and child endowment heterogeneity. This framework is applied to large American and British survey data on birth outcomes, with focus on the
Del Bono, Emilia, Ermisch, John, Francesconi, Marco   +2 more
core  

Pregnancy lipidomic profiles and DNA methylation in newborns from the CHAMACOS cohort. [PDF]

, 2019
Lipids play a role in many biological functions and the newly emerging field of lipidomics aims to characterize the varying classes of lipid molecules present in biological specimens.
Bradman, Asa, Eskenazi, Brenda, HOLLAND, Nina, Huen, Karen, Lee, Douglas, Tindula, Gwen   +5 more
core  

Randomized controlled trial of prolonged second stage: extending the time limit vs usual guidelines. [PDF]

, 2016
BACKGROUND: Guidelines for management of the second stage have been proposed since the 1800s and were created largely by expert opinion. Current retrospective data are mixed regarding differences in maternal and neonatal outcomes with a prolonged second ...
Berghella, Vincenzo, Gimovsky, Alexis C.
core   +2 more sources

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Maternal Outcomes Following Emergency Cesarean Delivery: Evaluating the Enhanced Recovery After Surgery Protocol in a Randomized Controlled Trial

Journal of Pharmacy and Bioallied Sciences
Aim: To evaluate the impact of the enhanced recovery after surgery (ERAS) protocol on maternal outcomes following emergency cesarean delivery (CD).
G. D. Abilashini, Divya Raghavendra Rao, Vijayalakshmi Gnanasekaran   +2 more
doaj   +1 more source

Adolescent Maternal Lifecourse Outcomes: Implications from an Integrated Mental Health Services Approach

Journal of Human Sciences and Extension, 2014
Family intervention literature on adolescent parenting describes the pathways between outcomes for adolescent mothers and their children and the contexts of the pregnancy itself (e.g., poverty, low or no prenatal care, lower educational attainment).
Beth S. Russell
doaj   +1 more source