Results 111 to 120 of about 89,266 (344)

The Moderating Effects of Sex on Consequences of Childhood Maltreatment: From Clinical Studies to Animal Models

Frontiers in Neuroscience, 2019
Stress has pronounced effects on the brain, and thus behavioral outputs. This is particularly true when the stress occurs during vulnerable points in development.
Jordon D. White, Arie Kaffman
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Maternal separation on postnatal stress in rats induces long-lasting changes on neurochemical, behavioural and genome responses [PDF]

, 2013
Early stress in life results in long-lasting effects in many neurotransmitter and neuroendocrine systems of the brain. Maternal separation (MS) is used an early life stressor that causes profound neurochemical and behavioural changes in the pups that ...
Acosta, Gabriela Beatriz
core   +1 more source

Upregulation of Netrin-1 in the hippocampus mediates the formation of visceral hypersensitivity induced by maternal separation [PDF]

, 2022
Junwen Wang, Guangbing Duan, Tingting Zhan, Zhiyu Dong, Yan Zhang, Ying Chen, Huihui Sun, Shuchang Xu   +7 more
openalex   +1 more source

Heightened Maternal Separation Anxiety in the Postpartum

Journal of Family Issues, 2013
Maternal separation anxiety (MSA) refers to feelings of anxiety elicited in a mother during separation from her infant. The role of social and structural disadvantage in the etiology of high MSA has been overlooked. Secondary analysis of data from the Longitudinal Study of Australian Children ( N = 3,897) revealed that compared to socioeconomically ...
Cooklin, Amanda R., Lucas, Nina, Strazdins, Lyndall, Westrupp, Elizabeth, Giallo, Rebecca, Canterford, Louise, Nicholson, Jan M.   +6 more
openaire   +3 more sources

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

The lived experiences of mothers regarding care of their hospitalised preterm babies [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 106-121).Trends in neonatal care aim to minimise separation of the baby from the mother in an effort to promote the well-being of both the mother and the baby, with proven positive effects on ...
Ncube, Rosinah Kereemang
core  

Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus

Frontiers in Molecular Neuroscience, 2019
Early life experiences program lifelong responses to stress. In agreement, resilience and vulnerability to psychopathologies, such as posttraumatic stress disorder (PTSD), have been suggested to depend on the early background. New therapies have targeted
Natividade de Sá Couto-Pereira, Natividade de Sá Couto-Pereira, Natividade de Sá Couto-Pereira, Carine Lampert, Aline dos Santos Vieira, Camilla Lazzaretti, Grasielle Clotildes Kincheski, Pablo Javier Espejo, Victor Alejandro Molina, Jorge Alberto Quillfeldt, Jorge Alberto Quillfeldt, Carla Dalmaz, Carla Dalmaz, Carla Dalmaz   +13 more
doaj   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system

Frontiers in Behavioral Neuroscience, 2015
Dysregulations in the brain serotonergic system and exposure to environmental stressors have been implicated in the development of major depressive disorder.
Peiyan eWong, Ying eSze, Laura Jane Gray, Cecilia Chin Roei Chang, Shiwei eCai, Xiaodong eZhang, Xiaodong eZhang, Xiaodong eZhang   +7 more
doaj   +1 more source