Results 111 to 120 of about 87,037 (303)

The Moderating Effects of Sex on Consequences of Childhood Maltreatment: From Clinical Studies to Animal Models

Frontiers in Neuroscience, 2019
Stress has pronounced effects on the brain, and thus behavioral outputs. This is particularly true when the stress occurs during vulnerable points in development.
Jordon D. White, Arie Kaffman
doaj   +1 more source

Heightened Maternal Separation Anxiety in the Postpartum

Journal of Family Issues, 2013
Maternal separation anxiety (MSA) refers to feelings of anxiety elicited in a mother during separation from her infant. The role of social and structural disadvantage in the etiology of high MSA has been overlooked. Secondary analysis of data from the Longitudinal Study of Australian Children ( N = 3,897) revealed that compared to socioeconomically ...
Cooklin, Amanda R., Lucas, Nina, Strazdins, Lyndall, Westrupp, Elizabeth, Giallo, Rebecca, Canterford, Louise, Nicholson, Jan M.   +6 more
openaire   +3 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus

Frontiers in Molecular Neuroscience, 2019
Early life experiences program lifelong responses to stress. In agreement, resilience and vulnerability to psychopathologies, such as posttraumatic stress disorder (PTSD), have been suggested to depend on the early background. New therapies have targeted
Natividade de Sá Couto-Pereira, Natividade de Sá Couto-Pereira, Natividade de Sá Couto-Pereira, Carine Lampert, Aline dos Santos Vieira, Camilla Lazzaretti, Grasielle Clotildes Kincheski, Pablo Javier Espejo, Victor Alejandro Molina, Jorge Alberto Quillfeldt, Jorge Alberto Quillfeldt, Carla Dalmaz, Carla Dalmaz, Carla Dalmaz   +13 more
doaj   +1 more source

Early Adolescent Separation Anxiety and Maternal Interactions.

, 1985
Attachment and separation in early adolescence were examined relative to maternal/child interactions and school achievement. Separation anxiety was measured by the Separation Anxiety Test, perceived maternal rejection and intrusiveness by the Child ...
Ardizzone, John Richard
core  

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system

Frontiers in Behavioral Neuroscience, 2015
Dysregulations in the brain serotonergic system and exposure to environmental stressors have been implicated in the development of major depressive disorder.
Peiyan eWong, Ying eSze, Laura Jane Gray, Cecilia Chin Roei Chang, Shiwei eCai, Xiaodong eZhang, Xiaodong eZhang, Xiaodong eZhang   +7 more
doaj   +1 more source

The different effects of maternal separation on spatial learning and reversal learning in rats

, 2015
Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day (PND) 1 to 21) on locomotor ...
Wang, Weiwen, Shao, Feng, Wang, Qiong, Shao, F, Li, Man, Du, Wei   +5 more
core   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source