Results 91 to 100 of about 87,037 (303)
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui +9 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Maternal separation (MS), a stressful event in early life, has been linked to neuropsychiatric disorders later in life, especially depression. In this study we investigated whether treatment with electroacupuncture (EA) could ameliorate depression ...
Yuanjia Zheng +12 more
doaj +1 more source
Maternal and professional identity change during the transition to motherhood [PDF]
, 2013 Becoming a mother derails many women’s chances for career progression. One reason for this is that women leave organisations when they become mothers, or reduce their working hours. Another reason is that people within the organisation start to view them
Kutzer, Roxanne
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Maternal separation reduces hippocampal pyramidal cell counts.
, 2013 Female (A) and male (B) rats exposed to maternal separation (MS – closed bars) display significantly reduced CA3c pyramidal cell numbers compared with rats exposed to early handling (EH – open bars) (ANOVA ...
Sandra Rees (344054) +5 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats
, 2013 As an adverse early life experience, maternal separation (MS) induces profound neurochemical, cognitive and emotional dysfunction. Previous studies have reported that MS affected prepulse inhibition (PPI), anxiety-related behaviors, dopaminergic and ...
Wang, Weiwen +5 more
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Maternal Separation and Emotional Reactivity in Balb/C Mice
, 1973 9 litters of BALB/c mice were divided into 3 groups: (a) a maternal separation group placed in an incubator during separation, (b) a non-incubated separation group, and (c) a non-separated control group. Beginning 24 hr.
Richard C. La Barba +2 more
core +1 more source
Advanced Science, EarlyView.In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu +11 more
wiley +1 more source
Advanced Science, EarlyView.In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li +10 more
wiley +1 more source
Maternal separation induces alterations of serotonergic system in different aged rats
, 2013 Maternal separation (MS) induces profound behavioral and neurochemical dysregulations in adult rodents. In the present longitudinal study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on serotonergic ...
Wang, Weiwen +4 more
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