Results 101 to 110 of about 1,453,231 (297)
TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains
Advanced Science, EarlyView.Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang +14 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2015 Dysregulations in the brain serotonergic system and exposure to environmental stressors have been implicated in the development of major depressive disorder.
Peiyan eWong +7 more
doaj +1 more source
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Maternal and professional identity change during the transition to motherhood [PDF]
, 2013 Becoming a mother derails many women’s chances for career progression. One reason for this is that women leave organisations when they become mothers, or reduce their working hours. Another reason is that people within the organisation start to view them
Kutzer, Roxanne
core +2 more sources
Maternal deaths in Australia 2008–2012 [PDF]
, 2015 This is the 16th report on women in Australia who die in association with pregnancy and childbirth. Authored by AIHW, Humphrey MD, Bonello MR, Chughtai A, Macaldowie A, Harris K and Chambers GM.
Michelle Bonello
core
Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly
Advanced Science, EarlyView.LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang +6 more
wiley +1 more source
Maternal mortality in high HIV prevalence countries: a critical analysis of the MMEIG methodology for estimating maternal mortality [PDF]
, 2012 Includes abstract.Includes bibliographical references.The main objective of this research is to analyse critically the methodology used by the Maternal Mortality Estimation Inter-Agency Group (MMEIG) to estimate maternal mortality in countries with high ...
Gotora, Tendai
core +1 more source
An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management
Advanced Science, EarlyView.Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer +12 more
wiley +1 more source
Meta-Analysis The Effect of Maternal Obesity on the Risk of Premature Birth and Neonatal Death
, 2021 Background: The prevalence of obesity in women of reproductive age worldwide is increasing by an estimated 20-36%. Increased prevalence of obesity also occurs in pregnant women. Obesity increases the risk of poor pregnancy outcome.
Budihastuti, Uki Retno +2 more
core
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source