Results 31 to 40 of about 82,948 (266)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Time series modelling and forecasting of mpox incidence and mortality in Nigeria

BMC Infectious Diseases
The World Health Organization (WHO) declared mpox a Public Health Emergency of International Concern (PHEIC) twice, in response to the global outbreak, first in May 2022 and again in August 2024, after a span of 2 years and 3 months.
Emmanuel Afolabi Bakare, Oluwaseun Akinlo Mogbojuri, Dolapo Oluwaseun Oniyelu, Afeez Abidemi, Deborah Oluwatobi Daniel, Idowu Isaac Olasupo, Samuel Abidemi Osikoya, Aaron Onyebuchi Nwana, Ronke Dorcas Olorunfemi, Samson Oluwafemi Olagbami   +9 more
doaj   +1 more source

The effect of travel restrictions on the geographical spread of COVID-19 between large cities in China: a modelling study

BMC Medicine, 2020
Background To contain the spread of COVID-19, a cordon sanitaire was put in place in Wuhan prior to the Lunar New Year, on 23 January 2020. We assess the efficacy of the cordon sanitaire to delay the introduction and onset of local transmission of COVID ...
Billy J. Quilty, Charlie Diamond, Yang Liu, Hamish Gibbs, Timothy W. Russell, Christopher I. Jarvis, Kiesha Prem, Carl A. B. Pearson, Samuel Clifford, Stefan Flasche, CMMID COVID-19 working group, Petra Klepac, Rosalind M. Eggo, Mark Jit   +13 more
doaj   +1 more source

Finite-Time Stabilization of Unstable Orbits in the Fractional Difference Logistic Map

Fractal and Fractional, 2023
A control scheme for finite-time stabilization of unstable orbits of the fractional difference logistic map is proposed in this paper. The presented technique is based on isolated perturbation impulses used to correct the evolution of the map’s ...
Ernestas Uzdila, Inga Telksniene, Tadas Telksnys, Minvydas Ragulskis   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Mathematical Model of a Micrometastasis [PDF]

Computational and Mathematical Methods in Medicine, 1997
Experimental evidence indicates that tumour metastases can exist for long periods in a dormant state, with cell proliferation balancing cell death. However, this balance can be upset, by removing the primary tumour for instance, which causes the metastasis to grow, or by adminstering a substances inhabiting angiogenesis which causes the metastasis toi ...
Malcolm Bloor, Michael Wilson
openaire   +1 more source

Estimating the duration of seropositivity of human seasonal coronaviruses using seroprevalence studies [version 2; peer review: 3 approved]

Wellcome Open Research, 2021
Background: The duration of immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still uncertain, but it is of key clinical and epidemiological importance.
Eleanor M. Rees, Naomi R. Waterlow, Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group, Rachel Lowe, Adam J. Kucharski   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Quantifying the impact of social groups and vaccination on inequalities in infectious diseases using a mathematical model

BMC Medicine, 2018
Background Social and cultural disparities in infectious disease burden are caused by systematic differences between communities. Some differences have a direct and proportional impact on disease burden, such as health-seeking behaviour and severity of ...
James D. Munday, Albert Jan van Hoek, W. John Edmunds, Katherine E. Atkins   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source