Results 51 to 60 of about 159,993 (313)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Quantifying the impact of social groups and vaccination on inequalities in infectious diseases using a mathematical model

BMC Medicine, 2018
Background Social and cultural disparities in infectious disease burden are caused by systematic differences between communities. Some differences have a direct and proportional impact on disease burden, such as health-seeking behaviour and severity of ...
James D. Munday, Albert Jan van Hoek, W. John Edmunds, Katherine E. Atkins   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Polynomial superlevel set representation of the multistationarity region of chemical reaction networks

BMC Bioinformatics, 2022
In this paper we introduce a new representation for the multistationarity region of a reaction network, using polynomial superlevel sets. The advantages of using this polynomial superlevel set representation over the already existing representations ...
AmirHosein Sadeghimanesh, Matthew England   +1 more
doaj   +1 more source

A Mathematical Model of a Micrometastasis [PDF]

Computational and Mathematical Methods in Medicine, 1997
Experimental evidence indicates that tumour metastases can exist for long periods in a dormant state, with cell proliferation balancing cell death. However, this balance can be upset, by removing the primary tumour for instance, which causes the metastasis to grow, or by adminstering a substances inhabiting angiogenesis which causes the metastasis toi ...
Malcolm Bloor, Michael Wilson
openaire   +1 more source

Connections of Science Capital and the Teaching and Learning of Mathematical Modelling: An Introduction

, 2020
This chapter is an introduction to the theoretical concept of science capital. It also serves as an introduction to the next three chapters of this book. These ensuing chapters all connect mathematical modelling education to science capital.
Pauline Vos, Peter Frejd, Frejd, Peter,, Hernandez-Martinez, Paul,, Vos, Pauline,, Paul Hernandez-Martinez   +5 more
core   +1 more source

The challenge of modelling aggregated human behaviour [PDF]

, 2013
Mathematical modelling is a blooming area of applied mathematics, and it is not yet sixty years old. At its beginning, engineers were the main practitioners of this new area of mathematics, developing mathematical models for solving engineering ...
Acedo Rodríguez, Luis, Jódar Sánchez, Lucas Antonio, Cortés, J.-C.   +2 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Enhancing Unmanned Aerial Vehicle Object Detection via Tensor Decompositions and Positive–Negative Momentum Optimizers

Mathematics
The current development of machine learning has advanced many fields in applied sciences and industry, including remote sensing. In this area, deep neural networks are used to solve routine object detection problems, satisfying the required rules and ...
Ruslan Abdulkadirov, Pavel Lyakhov, Denis Butusov, Nikolay Nagornov, Dmitry Reznikov, Anatoly Bobrov, Diana Kalita   +6 more
doaj   +1 more source

A mathematical model of Marburg virus disease outbreaks and the potential role of vaccination in control

BMC Medicine, 2023
Background Marburg virus disease is an acute haemorrhagic fever caused by Marburg virus. Marburg virus is zoonotic, maintained in nature in Egyptian fruit bats, with occasional spillover infections into humans and nonhuman primates.
George Y. Qian, W. John Edmunds, Daniel G. Bausch, Thibaut Jombart   +3 more
doaj   +1 more source