Results 31 to 40 of about 2,127,022 (301)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Study of Szász–Durremeyer-Type Operators Involving Adjoint Bernoulli Polynomials

Mathematics
This research work introduces a connection of adjoint Bernoulli’s polynomials and a gamma function as a sequence of linear positive operators. Further, the convergence properties of these sequences of operators are investigated in various functional ...
Nadeem Rao, Mohammad Farid, Rehan Ali
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A metric approach to limit operators

, 2017
We extend the limit operator machinery of Rabinovich, Roch, and Silbermann from Z^N to (bounded geometry, strongly) discrete metric spaces. We do not assume the presence of any group structure or action on our metric spaces.
Spakula, Jan, Willett, Rufus
core   +1 more source

Operational Calculus of the Quantum Statistical Fermi–Dirac and Bose–Einstein Functions Leading to the Novel Fractional Kinetic Equations

Fractal and Fractional
The sun is a fundamental element of the natural environment, and kinetic equations are crucial mathematical models for determining how quickly the chemical composition of a star like the sun is changing. Taking motivation from these facts, we develop and
Asifa Tassaddiq, Carlo Cattani, Rabab Alharbi, Ruhaila Md Kasmani, Sania Qureshi   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Thirty-first Illinois Custom Spray Operators Training School: summaries of presentations [PDF]

, 1979
Made available in DSpace on 2016-03-17T21:24:49Z (GMT). No. of bitstreams: 2 749322_1979.pdf: 25608937 bytes, checksum: a190a7b2270aef124526f80493eb0a69 (MD5) license.txt: 4846 bytes, checksum: 927d59ba442de31571446841df3d90ca (MD5) Previous issue date:
Illinois Custom Spray Operators' School
core  

An Application of Multiple Erdélyi–Kober Fractional Integral Operators to Establish New Inequalities Involving a General Class of Functions

Fractal and Fractional
This research aims to develop generalized fractional integral inequalities by utilizing multiple Erdélyi–Kober (E–K) fractional integral operators. Using a set of j, with (j∈N) positively continuous and decaying functions in the finite interval a≤t≤x ...
Asifa Tassaddiq, Rekha Srivastava, Rabab Alharbi, Ruhaila Md Kasmani, Sania Qureshi   +4 more
doaj   +1 more source

Generalized k-Fractional Chebyshev-Type Inequalities via Mittag-Leffler Functions

Axioms, 2022
Mathematical inequalities have gained importance and popularity due to the application of integral operators of different types. The present paper aims to give Chebyshev-type inequalities for generalized k-integral operators involving the Mittag-Leffler ...
Zhiqiang Zhang, Ghulam Farid, Sajid Mehmood, Chahn-Yong Jung, Tao Yan   +4 more
doaj   +1 more source