Results 41 to 50 of about 1,385,828 (305)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Learning from Euler. From Mathematical Practice to Mathematical Explanation

open access: yesPhilosophia Scientiæ, 2012
In his "Découverte d'un nouveau principe de mécanique" (1750) Euler offered, for the first time, a proof of the so-called Euler's Theorem. In this paper I will focus on Euler's original proof and I will show how a look at Euler's practice as a ...
Daniele Molinini
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Teachers’ Accounts of Developing Mathematical Resilience in the Classroom [PDF]

open access: yes, 2017
This paper reports on a professional development programme in mathematical resilience, and the experiences of the teachers taking part. The programme introduced the teachers to the construct of mathematical resilience, and explained how it was relevant ...
Lee, Clare, Ward-Penny, Robert
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Practice, Constraint, and Mathematical Concepts

open access: yesPhilosophia Scientiæ, 2012
In this piece I articulate and defend a conception of mathematical practice and mathematical subject-matter, which is responsive both to a sensible pluralism concerning the connection between inferential practices and guiding interests, on the one hand ...
Mark C. R. Smith
doaj   +1 more source

Mathematical Resilience as a Conceptual Framework for School Practice

open access: yesMultidisciplinary Journal of School Education, 2022
The aim of the study is to analyze mathematical resilience from theoretical and practical perspectives. The paper is based on a review of the literature.
URSZULA OSZWA
doaj   +1 more source

Of the use of the “English sector” in trigonometry: what amount of mathematical training was necessary in the 18th century? [PDF]

open access: yes, 2016
In 1723 Edmund Stone published The construction and principal uses of mathematical instruments, which was essentially a translation from the French of Bion’s Traité de la construction et des principaux usages des instrumens de mathématique (1709).
Blanco Abellán, Mónica
core   +2 more sources

On the integration of digital technologies into mathematics classrooms [PDF]

open access: yes, 2004
Trouche‘s (2003) presentation at the Third Computer Algebra in Mathematics Education Symposium focused on the notions of instrumental genesis and of orchestration: the former concerning the mutual transformation of learner and artefact in the course of ...
Hoyles, Celia   +2 more
core   +3 more sources

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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