Results 41 to 50 of about 149,591 (264)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lange on Mathematical Explanation, Grounding, and the Divergence Thesis

Crítica
Mark Lange has defended the view that mathematical explanation and grounding explanation diverge. In this paper, I argue that at least one type of grounding relation is immune to his criticisms. After fixing a minimal separatist theory of ground, I show
Mohammad Maarefi
doaj   +1 more source

Learning from Euler. From Mathematical Practice to Mathematical Explanation

Philosophia Scientiæ, 2012
In his "Découverte d'un nouveau principe de mécanique" (1750) Euler offered, for the first time, a proof of the so-called Euler's Theorem. In this paper I will focus on Euler's original proof and I will show how a look at Euler's practice as a ...
Daniele Molinini
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Practical Mathematics [PDF]

Nature, 1900
n ...
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Practice, Constraint, and Mathematical Concepts

Philosophia Scientiæ, 2012
In this piece I articulate and defend a conception of mathematical practice and mathematical subject-matter, which is responsive both to a sensible pluralism concerning the connection between inferential practices and guiding interests, on the one hand ...
Mark C. R. Smith
doaj   +1 more source

Mathematical game performance as an indicator of deliberate practice

International Journal of Serious Games, 2023
The traditional classroom setting presents challenges when it comes to strengthening adaptive expertise in mathematics education through deliberate practice.
Jake McMullen, Phuong Bui, Boglárka Brezovszky, Erno Lehtinen, Minna Hannula-Sormunen   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Longitudinal study of gastroesophageal reflux and erosive tooth wear

BMC Gastroenterology, 2017
Background Approximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms.
Clive H. Wilder-Smith, Andrea Materna, Lukas Martig, Adrian Lussi   +3 more
doaj   +1 more source