Results 81 to 90 of about 458,493 (298)
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Mating system and population genetic structure of the bulldog ant Myrmecia pavida [PDF]
, 2013 Understanding the evolution of the alternative mating strategies of monandry and polyandry is a fundamental problem in evolutionary biology because of the cost-benefit trade-offs associated with mating for females.
Baer, Boris +3 more
core +1 more source
Female mating preferences in blind cave tetras Astyanax fasciatus (Characidae, Teleostei). [PDF]
, 2006 The Mexican tetra Astyanax fasciatus has evolved a variety of more or less color- and eyeless cave populations. Here we examined the evolution of the female preference for large male body size within different populations of this species, either surface-
Plath, Martin +4 more
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Thermoregulatory Requirements Shape Mating Opportunities of Male Proboscis Bats
Frontiers in Ecology and Evolution, 2018 The spatiotemporal distribution of females is a major factor affecting animal social systems. Predation risk and the distribution of feeding resources often determine where females are found, but abiotic factors (e.g., temperature) can also shape the ...
Luke R. Wilde +6 more
doaj +1 more source
Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. [PDF]
, 2015 The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised
Abdou +90 more
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Frontiers in Ecology and Evolution, 2019 Animal mating systems have fascinated biologists for thousands of years. Ways to describe a mating system include determining social organization, observing copulations, or using genetics to assign parentage.
John L. Hoogland +2 more
doaj +1 more source
MicroRNAs influence reproductive responses by females to male sex peptide in Drosophila melanogaster [PDF]
, 2014 Across taxa, female behavior and physiology changes significantly following the receipt of ejaculate molecules during mating. For example, receipt of sex peptide (SP) in female Drosophila melanogaster significantly alters female receptivity, egg ...
Chapman, Tracey +4 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source