Results 121 to 130 of about 13,912,764 (337)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2009 The opportunistic fungal pathogen Candida glabrata is the second most common isolate from bloodstream infections worldwide and is naturally less susceptible to the antifungal drug fluconazole than other Candida species. C.
María Teresa Lavaniegos-Sobrino +7 more
doaj +1 more source
Mating type loci in H.pseudoalbidus
, 2014 Mating-type loci analysis. Upper portion: The MAT locus in the KW1 isolate was identified in the genome sequence. A DNA polymerase zeta catalytic subunit was identified by tblastn of the region between the SLA2 and MAT1-1-3 genes against the NCBI nr ...
Diane Saunders (554467) +1 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
HorticulturaeLentinula edodes (shiitake) is a globally significant edible mushroom, with China being its largest producer. Efficient breeding is fundamental to sustaining its industry, yet it is often hindered by the labor-intensive and time-consuming nature of ...
Xiangqian Wang +9 more
doaj +1 more source
Activation of the Mating Pheromone Response Pathway of Lentinula edodes by Synthetic Pheromones
Mycobiology, 2018 Pheromone (PHB)-receptor (RCB) interaction in the mating pheromone response pathway of Lentinula edodes was investigated using synthetic PHBs. Functionality of the C-terminally carboxymethylated synthetic PHBs was demonstrated by concentration-dependent ...
Byeongsuk Ha +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Karakteristik morfologi dan sebaran tipe kawin Phytophthora capsici asal lada di Pulau Jawa
Jurnal Fitopatologi Indonesia, 2019 Morphology characters and mating types distribution of Phytophthora capsici from black pepper in Java Island Pepper (Piper nigrum) is one of the most important spice crops in Indonesia.
Bahru Rohmah +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source