Results 141 to 150 of about 13,912,764 (337)
Plant DirectDistyly is a reproductive system, characterized by the presence of two floral morphs, which promotes outcrossing via physical and biochemical means. In distylous Turnera, the mating type of the S‐morph is determined by two genes: YUC6 (male) and BAHD ...
Paige M. Henning +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Duration of courtship effort as a costly signal
, 2009 We consider a male and a female in a courtship encounter over continuous time. Both parties pay participation costs per unit time. The game ends when either one or other of the parties quits or the female accepts the male as a mate.
Sozou, PD +4 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mating type tests using a plating technique
, 1962 Mating type tests using a plating ...
Smith, B. R., B. R. Smith
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Universality of the Phytophthora mating hormones and diversity of their production profile
Scientific Reports, 2017 Sexual reproduction of the plant pest Phytophthora is regulated by two mating hormones α1 and α2, which are acyclic oxygenated diterpenes first isolated from P. nicotianae A1 and A2 mating types, respectively. A previous report suggested the universality
Tomohiko Tomura +3 more
doaj +1 more source
Mating-type region and mating-type switching in S. pombe.
, 2013 (A) Schematic representation of the mating-type region showing the expressed, switchable, mat1 locus and the silent mat2-P and mat3-M donor loci. Elements are described in the text.
Geneviève Thon (13482) +4 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source