Results 51 to 60 of about 206,549 (259)

MATING TYPE AND SPORULATION IN YEAST I. MUTATIONS WHICH ALTER MATING-TYPE CONTROL OVER SPORULATION [PDF]

Genetics, 1975
ABSTRACT Fifty-two inositol-requiring mutants of Saccharomyces cerevisiae were isolated following mutagenesis with ethyl methanesulfonate. Complementation and tetrad analysis revealed ten major complementation classes, representing ten independently segregating loci (designated ino1 through ino10) which recombined freely with their ...
A K, Hopper, B D, Hall
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Regulation of mating type switching by the mating type genes and RME1 in Ogataea polymorpha [PDF]

Scientific Reports, 2017
Abstract Saccharomyces cerevisiae and its closely related yeasts undergo mating type switching by replacing DNA sequences at the active mating type locus ( MAT ) with one of two silent mating type cassettes. Recently, a novel mode of mating type switching
Katsuyoshi Yamamoto, Thi N. M. Tran, Kaoru Takegawa, Yoshinobu Kaneko, Hiromi Maekawa   +4 more
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

High variability in a mating type linked region in the dry rot fungus Serpula lacrymans caused by frequency-dependent selection?

BMC Genetics, 2010
Background The mating type loci that govern the mating process in fungi are thought to be influenced by negative frequency-dependent selection due to rare allele advantage.
Sætre Glenn-Peter, Skrede Inger, Engh Ingeborg, Kauserud Håvard   +3 more
doaj   +1 more source

Allelic exchange of pheromones and their receptors reprograms sexual identity in Cryptococcus neoformans. [PDF]

PLoS Genetics, 2010
Cell type specification is a fundamental process that all cells must carry out to ensure appropriate behaviors in response to environmental stimuli.
Brynne C Stanton, Steven S Giles, Mark W Staudt, Emilia K Kruzel, Christina M Hull   +4 more
doaj   +1 more source

Mating Types in Stylonychia putrina.

Experimental Biology and Medicine, 1952
Although conjugation in ciliated Protozoa was long extensively studied, especially by Maupas(1), mating types were first discovered by Sonneborn(2). It is now known that mating types exist in Paramecium aurelia(2,3) P. bursaria(4-6), P. caudatum(7-11), P. multimicronucleatum(11), P. trichium(12), P. calkinsi(12-14), and Euplotes patella(15). In several
openaire   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Distribution of Two Mating-Type Idiomorphs in Commercially Cultivated Morchella sextelata Unveiling Unique Life Cycle of Morels

Horticulturae
The outdoor cultivation of true morels has been successfully commercialized in China in recent years. However, unstable yields make it a high-risk business.
Jingting Wang, Dezheng Zhu, Xiaobo Li, Xia Gao, Yan Zhang, Meixiu Liu, Weidong Lu, Lili Xu, Hao Yu, Xiuqing Yang   +9 more
doaj   +1 more source