Results 91 to 100 of about 144,724 (296)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Sexual selection and sex allocation in a simultaneous hermaphrodite [PDF]
, 2010 Since Darwin’s pioneering work, sexual selection theory has become a unifying framework in evolutionary biology successfully explaining the variation in sexual dimorphism, reproductive strategies and mating systems. Although, it has long been argued that
Janicke, Tim
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Determination of mating types through antibiotic resistance phenotypes in Cryptococcus neoformans
Journal of Applied Sciences and Environmental Management, 2019 Cryptococcus neoformans is best known as a life threatening pathogen that infest majorly immuocompromised individual. In this work, two isolates; one clinical CD4832 and environmental NMB5 selected and confirmed based on their melanin production on ...
L Eboigbe, J.E. Usiosefe
doaj +1 more source
A PCR-based Assay for Distinguishing between A1 and A2 Mating Types of Phytophthora capsici
, 2017 Sexual reproduction in the plant parasite Phytophthora capsici Leonian requires the interaction of two distinct mating types, A1 and A2. Co-occurrence of these mating types can enhance the genetic diversity of P.
Fangxin Chen +6 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Both mating types in the heterothallic fungus Ophiostoma quercus contain MAT1-1 and MAT1-2 genes [PDF]
, 2012 In heterothallic Ascomycota, two opposite but distinct mating types control all sexual processes. Using mating crosses, mating types were assigned to ten isolates of the heterothallic fungal species Ophiostoma quercus.
Wingfield, Brenda D. +5 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of FungiPolyporus umbellatus is a species whose sclerotia have been extensively employed in traditional Chinese medicine, which has diuretic, antitumor, anticancer, and immune system enhancement properties. However, prolonged asexual reproduction has resulted in
Shoujian Li +4 more
doaj +1 more source