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Matrine: Bioactivities and Structural Modifications
Current Topics in Medicinal Chemistry, 2016Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity ...
Hui Xu
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Evolution of matrinic ethanol derivatives as anti-HCV agents from matrine skeleton
Bioorganic & Medicinal Chemistry Letters, 2017Twenty-two novel 12N-substituted matrinic ethanol derivatives were synthesized and evaluated for their antiviral activities against HCV taking compound 1 as the lead. The SAR study indicated that the shortening of the 11-butyl chain to ethyl chain did not affect the activity significantly. Out of the target compounds, matrinic ethanol 6a demonstrated a
Ying-Hong, Li +7 more
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Antiviral Effect of Matrine against Human Enterovirus 71
Molecules, 2012 Human enterovirus 71, a member of the <em>Picornaviridae</em> family, is one of the major causative agent of hand, foot and mouth disease in children less than six years old. This illness has caused mortalities in large-scale outbreaks in the
Jiangning Liu, Chuan Qin, Yajun Yang
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On the absolute configuration of matrine: Crystal structure of matrin-1-IUM-trichlorozincate
Journal of Structural Chemistry, 2009The title compound crystallizes in the monoclinic space group P21 with a = 7.804(1)A, b = 13.597(2) A c = 9.093(1) A, β= 108.41(1)°, V = 915.5(2)A3, Z = 4, R = 0.0231, wR2 = 0.0475 (Siemens P4 diffractometer with MoK α radiation, 3994 reflections collected at room temperature, 204 parameters refined).
Z. M. Jin, L. L. Ma, W. X. Wei, Y. Q. Li
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An x-ray structural investigation of cis-matrine — A new stereoisomer of matrine
Chemistry of Natural Compounds, 1981In an investigation of the three-dimensional structure of the alkaloid matrine by x-ray structural analysis, a new stereoisomer of it has been detected, which has been called cis-matrine. In cis-matrine rings C and D are cis-linked, while the configurations of the A, B, and C fragments in cis-matrine and in ordinary matrine are identical.
B. T. Ibragimov +3 more
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Stereoisomerism of the matrine alkaloids
Chemistry of Natural Compounds, 1982The stereoisomerism of compounds of the matrine series is considered on the basis of the authors' own x-ray structural studies of these alkaloids. A corrected series of eight stereoisomers has been drawn up. It has been shown that the numbers of theoretically possible stereoisomers of matrine is thirty-two.
B. T. Ibragimov +4 more
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Total synthesis of (±)-matrine
J. Chem. Soc., Chem. Commun., 1986The total synthesis of matrine based on a N-acyliminium ion cyclization as the key step to construct the tetracyclic skeleton, and the X-ray crystal structure of 8-oxomatrine, are reported.
Jen Chen +2 more
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[HPCE determination of matrine in matrine liposome].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2007To establish an HPCE method for the determination of matrine in Matrine Liposome.HPCE was used. The best condition was achieved with a fused silica capillary tube( 150 cm x 75 microm), 0.25 mol/L phosphate buffer (pH 6.8), at constant voltage of 20 kV and temperature at 25 degrees C.
Xiu-ming, Zhang, Xiao-ping, Liu, Hui, Li
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Ocular Anti-Inflammatory Actions of Matrine
Journal of Ocular Pharmacology and Therapeutics, 1987Matrine is an alkaloid isolated from the root of Sophora subprostrata (Leguminosae) which has been used as a Chinese medicine for the treatment of inflammation. Instillation of 50 microliter of 1% matrine showed significant inhibition of ocular inflammation induced by lens proteins. Unlike corticosteroids, matrine did not facilitate the IOP recovery in
C Y, Chuang, J G, Xiao, G C, Chiou
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Journal of Chromatography B, 2011
A matrine-imprinted monolithic stationary phase (MIP monolith) was prepared by in situ polymerization for extraction and purification of matrine from Sophorae flavescentis Ait. Matrine was used as the template molecule, methacrylic acid as the function monomer, ethylene glycol dimethacrylate as the cross-linking agent, and toluene and dodecanol as the ...
Qiang, Fu +7 more
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A matrine-imprinted monolithic stationary phase (MIP monolith) was prepared by in situ polymerization for extraction and purification of matrine from Sophorae flavescentis Ait. Matrine was used as the template molecule, methacrylic acid as the function monomer, ethylene glycol dimethacrylate as the cross-linking agent, and toluene and dodecanol as the ...
Qiang, Fu +7 more
openaire +2 more sources