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Anticancer Advances of Matrine and Its Derivatives
Current Pharmaceutical Design, 2015As the second leading cause of death in the world, the total number caused by cancer in 2008 is 1.4 million. The great cancer incidence worldwide increases the search for new, safer and efficient anticancer agents (especially to find the new structures and more active anticancer drugs from the natural products) aiming the prevention or the cure of such
Jianping, Yong +2 more
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Structural Modifications of Matrine-Type Alkaloids
Mini-Reviews in Medicinal Chemistry, 2018Matrine-type alkaloids belong to quinolizidine analogues from Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L. possess numerous therapeutic properties and have attracted continuous attention over the past few decades. In order to improve the activities and amplify their applicants, many matrine-type derivatives have synthesized
Xiao-Hua, Cai, Hui, Guo, Bing, Xie
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Study on pharmacokinetics of matrine by intramuscularadministration in rat
China Journal of Chinese Matera Medica, 2010To study the pharmacokinetics of matrine (MT) intramuscular administration in rat.Plasma concentration of matrine was determined by HPLC under the following conditions: column (Shim-pack VP-ODS, 4. 6 mm x 150 mm, 5 m); eluent (acetonitrile-0.02 mol ammonium acetate buffer-triethylamine 30: 70: 0.04); flow rate was 1 mL x min(-1) and ultraviolet ...
Chenguang, Zhao +3 more
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On the Stereochemistry of Matrine-Type Alkaloids
Chemistry of Natural Compounds, 2018Data from the CCDC were analyzed to prove that cis-matrine is a nonexistent quasi-diastereomer. The proposed existence of 32 enantiomeric pairs in nature (considering the N atoms as chiral centers) was incorrect.
B. Tashkhodzhaev, V. I. Vinogradova
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Derivatives and sterochemistry of the matrine alkaloids
Chemistry of Natural Compounds, 1971α-Substituted derivatives of the isomeric matrines and a new isomer of sophocarpine—13, 14-dehydroisosophoridine—have been synthesized.
S. Iskandarov +3 more
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Thermodynamic Properties of Matrine in Ethanol
International Journal of Thermophysics, 2011In this paper, the enthalpies of dissolution of matrine in ethanol (EtOH) were measured using a RD496-2000 Calvet microcalorimeter at 309.65 K under atmospheric pressure. The differential enthalpy (Δdif H m) and molar enthalpy (Δsol H m) of dissolution of ...
Z. X. Li, W. W. Zhao, X. H. Pu
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011
To establish a new method for the determination of matrine in matrine injection by microfluidic chip with contactless conductivity detection.The electrophoretic parameters, such as the variety and concentration of buffer solution and additive, separation voltage and injection time, etc.
Chong, Wang +4 more
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To establish a new method for the determination of matrine in matrine injection by microfluidic chip with contactless conductivity detection.The electrophoretic parameters, such as the variety and concentration of buffer solution and additive, separation voltage and injection time, etc.
Chong, Wang +4 more
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Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine
Chemico-Biological Interactions, 2009Matrine (Mat), a component extracted from Sophora flavescens Ait, has a wide spectrum of pharmacological effects. Glycyrrhizin (Gly), a major active constituent of licorice (Glycyrrhiza glabra) root, has various pharmacological effects. Gly and Mat are ancillary drugs used clinically in China for protection of liver function and treatment of tumors ...
Xu-ying, Wan +3 more
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Determination of matrine in Fufang Shen'an granules by HPLC
China Journal of Chinese Materia Medica, 2010To determination the content of matrine in Fufang Shen'an particles by HPLC.HPLC with Dikma Diamonsil C18 (4.6 mm x 150 mm, 5 microm) column was used. Acetonitrile-0.1% H3 PO4 (22:78) as the mobile phase, flow rate was 1.0 mL x min(-1) and the UV detection wavelength was 220 nm.The linear range of matrine was 2.08-10.40 microg, the correlation ...
Weiping, Liu, Zheng, Ruan, Mei, Bai
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[Pharmacokinetics of matrine in healthy volunteers].
Yao xue xue bao = Acta pharmaceutica Sinica, 1994A sensitive high performance liquid chromatographic analytical method was established for determining the concentration of matrine in human serum. The recovery of matrine was 99.1-102.2%. The RSD (%) in within-day and between-days were no more than 6%. The calibration curve was linear in the range from 1.25 micrograms.ml-1 to 40.0 micrograms.ml-1 with ...
P Q, Wang +6 more
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