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[Toxicity of matrine in Kunming mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011To investigate the acute toxicity and assess the median lethal dose (LD50) of matrine in Kunming mice.Matrine at different doses were administered in Kunming mice via intraperitoneal injection, and the toxic reactions and LD50 of matrine was observed and determined.The acute toxicity test of matrine indicated that the tolerable dose of matrine was ...
Xiao-yan, Wang +4 more
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[Advance in the pharmacological research on matrine].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2004The progress in the research on matrine was involved to provide references for the exploitation and utilization of the matrine.Pharmacological functions and mechanism were reviewed according to related experimental studies.Matrine has various pharmacological activities.Matrine has extensive applied prospect and will be developed further.
Mei, Liu +2 more
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[Pharmacokinetics and pharmacodynamics of matrine and oxymatrine].
Yao xue xue bao = Acta pharmaceutica Sinica, 1993On measuring the percentage of QTc interval prolongation, the pharmacokinetic and pharmacodynamic profiles of i.v. matrine or oxymatrine in rabbits were analyzed by combined pharmacokinetic and pharmacodynamic model. The plasma concentration--time profiles of the two drugs can be described by a two--compartment open model, and the relationship between ...
X H, Wang, S K, Huang
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[Anti-arrhythmic effects of matrine].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT.
B H, Zhang +4 more
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Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis
Inflammation, 2023Yun Yu, Yuhong Xiao
exaly
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice
Acta Pharmacologica Sinica, 2020Zhen-Guo Ma, Hai-Ming Wu, Qi-Zhu Tang
exaly
Antipruritic Effect of Matrine
Journal of Cell Signaling, 2018Mei Yu, Zongxiang Tang
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