Results 91 to 100 of about 322,605 (305)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Instantons in sine-Liouville theory
Journal of High Energy PhysicsWe compute instanton corrections to the partition function of sine-Liouville (SL) theory, which provides a worldsheet description of two-dimensional string theory in a non-trivial tachyon background.
Sergei Alexandrov +2 more
doaj +1 more source
Abstract and Applied Analysis, 2013 This paper considers dynamical behaviors of a class of fuzzy impulsive reaction-diffusion delayed cellular neural networks (FIRDDCNNs) with time-varying periodic self-inhibitions, interconnection weights, and inputs.
Guowei Yang, Yonggui Kao, Changhong Wang
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Cautionary Note on Using Univariate Methods for Meta-Analytic Structural Equation Modeling
Advances in Methods and Practices in Psychological ScienceMeta-analytic structural equation modeling (MASEM) is an increasingly popular technique in psychology, especially in management and organizational psychology. MASEM refers to fitting structural equation models (SEMs), such as path models or factor models,
Suzanne Jak, Mike W.-L. Cheung
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Matrix-Analytic Methods in Stochastic Models
, 1996 Based on the proceedings of the first International Conference on Matrix-Analytic Methods (MAM) in Stochastic Models, held in Flint, Michigan, this book presents a general working knowledge of MAM through tutorial articles and application papers.
Alfa, Attahiru S. +1 more
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Matrix analytic methods with Markov decision processes for hydrological applications. [PDF]
, 2014 In general, a physical process is modelled in terms of how its state evolves over time. The main challenge of modelling is to describe this evolution without unnecessary computation or making unrealistic simplifying assumptions.
Fisher, Aiden James
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Solution of the Least Squares Method problem of pairwise comparison matrices [PDF]
, 2008 The aim of the paper is to present a new global optimization method for determining all the optima of the Least Squares Method (LSM) problem of pairwise comparison matrices. Such matrices are used, e.g., in the Analytic Hierarchy Process (AHP).
Bozóki, Sándor
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source