Results 101 to 110 of about 322,605 (305)

Matrix-analytic Methods for the Evolution of Species Trees, Gene Trees, and Their Reconciliation

Methodology and Computing in Applied Probability
Abstract We consider the reconciliation problem, in which the task is to find a mapping of a gene tree into a species tree. In this paper we present a method, where for a given choice of parameters, we are able to compute the likelihood for alternative reconciliations.
Albert Ch. Soewongsono, Jiahao Diao, Tristan Stark, Amanda E. Wilson, David A. Liberles, Barbara R. Holland, Małgorzata M. O’Reilly   +6 more
openaire   +2 more sources

Periodic review base-stock replenishment policy with endogenous lead times. [PDF]

In this paper, we consider a two stage supply chain where the retailer's inventory is controlled by the periodic review, base-stock level (R,S) replenishment policy and the replenishment lead times are endogenously generated by the manufacturer's ...
Boute, Robert, Lambrecht, Marc, Van Houdt, B   +2 more
core  

User needs elicitation via analytic hierarchy process (AHP). A case study on a Computed Tomography (CT) scanner [PDF]

, 2013
Background: The rigorous elicitation of user needs is a crucial step for both medical device design and purchasing. However, user needs elicitation is often based on qualitative methods whose findings can be difficult to integrate into medical decision ...
Ragozzino, Angela, Jennifer L Martin, Luciano Mirarchi, Morgan, Stephen P., Stephen P Morgan, Martin, Jennifer L., Mirarchi, Luciano, Angela Ragozzino, Leandro Pecchia, Arturo Scognamiglio, Carmela Vanzanella, Scognamiglio, Arturo, Pecchia, Leandro, Vanzanella, Carmela   +13 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Matrix-Analytic Methods in Queueing Theory

, 2015
Analytical methods for tractable (Markov) queueing models commonly assume Poisson arrivals and exponential service. The assumptions are unrealistic from a modeling point of view.
Huang, Anqi
core  

Tuning Natural Deduction Proof Search by Analytic Methods [PDF]

, 2018
This paper is a result of the analysis of the efficiency of natural deduction proof search and the major weaknesses affecting it. We introduce new analytic strategies based on a new concept ”Truth Set of Support”.
Bolotov, A., Gorchakov, A.
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PraFL: A Single-Round Analytic Paradigm for Privacy-Preserving and Heterogeneity-Robust Federated Learning

IEEE Access
The exponential proliferation of edge-generated data necessitates robust Federated Learning (FL) frameworks, yet statistical heterogeneity and severe data scarcity in decentralized environments persistently compromise model generalization and exacerbate ...
Wang Lei, Jasni Mohamad Zain, Nur Atiqah Sia Abdullah, Md. Arafatur Rahman, Hai Tao, Ali H. Alenezi   +5 more
doaj   +1 more source

Matrix-analytic methods in supply chain management: recent developments

, 2012
Matrix-analytic methods are a popular modeling tool in a great number of fields, most notable in the analysis of telecommunication systems. Because of their ability to construct and analyze a wide class of stochastic mod els, they can also be applied in ...
Creemers, S., Noblesse, Ann, Boute, Robert, Colen, P., Van Houdt, Benny, Noblesse, A., Colen, Pieter, Van Houdt, B., Boute, R., Creemers, Stefan   +9 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source