Results 61 to 70 of about 7,283,251 (294)

Commuting Quantum Matrix Models [PDF]

, 2014
We study a quantum system of $p$ commuting matrices and find that such a quantum system requires an explicit curvature dependent potential in its Lagrangian for the system to have a finite energy ground state.
Filev, Veselin G., O'Connor, Denjoe
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Matrix thermalization [PDF]

Journal of High Energy Physics, 2017
Matrix quantum mechanics offers an attractive environment for discussing gravitational holography, in which both sides of the holographic duality are well-defined. Similarly to higher-dimensional implementations of holography, collapsing shell solutions in the gravitational bulk correspond in this setting to thermalization processes in the dual quantum
Craps, Ben, Evnin, Oleg, Nguyen, Kévin
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Low-temperature sequential deposition for efficient inverted perovskite solar cells

Nature Communications
Inverted perovskite solar cell has made significant progress in recent years. Although two-step sequential deposition shows the benefits to obtain higher quality large-size perovskite crystals, the high annealing temperature, which is required to achieve
Mengjiong Chen, Zhenzhen Qin, Ziyang Zhang, Wenxiang Xiang, Yingming Liu, Chuang Tian, Siyuan Chen, Yanbo Wang, Liyuan Han   +8 more
doaj   +1 more source

Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells

npj Regenerative Medicine, 2023
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation.
Alejandro M. Chibly, Vaishali N. Patel, Marit H. Aure, Mary C. Pasquale, NIDCD/NIDCR Genomics and Computational Biology Core, Gemma E. Martin, Mousa Ghannam, Julianne Andrade, Noah G. Denegre, Colleen Simpson, David P. Goldstein, Fei-Fei Liu, Isabelle M. A. Lombaert, Matthew P. Hoffman   +13 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy

Communications Chemistry, 2022
Site-selective thionation is a powerful strategy to access heavyatom-free small-molecule photosensitizers for photodynamic therapy. Here, a series of sulfur-substituted benzothioxanthene chromophores is synthesized and the sequential insertion of sulfur ...
Marco Deiana, Pierre Josse, Clément Dalinot, Artem Osmolovskyi, Pablo Simón Marqués, José María Andrés Castán, Laura Abad Galán, Magali Allain, Lhoussain Khrouz, Olivier Maury, Tangui Le Bahers, Philippe Blanchard, Sylvie Dabos-Seignon, Cyrille Monnereau, Nasim Sabouri, Clément Cabanetos   +15 more
doaj   +1 more source