Results 51 to 60 of about 81,093 (306)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Measuring pair wised comparisons matrix inconsistency ratio in fuzzy hierarchical structure [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2012
The Analytic Hierarchical Process (AHP) determines the relativeimportance of a set of alternatives in a multi-criteria decision problem.AHP has a hierarchial structure and based on pairwise comparisons ofthe project alternatives as well as pairwise ...
Mohammad Hosein Arman, Jamshid Salehi Sadaghiyani, Sara Mojdehi, Ali Nazarli   +3 more
doaj  

Using exploratory factor analysis in personality research: Best-practice recommendations

SA Journal of Industrial Psychology, 2010
Orientation: Exploratory factor analysis is the method of choice with objective personality instruments, particularly to establish the construct validity and construct equivalence of trait-based instruments.
Sumaya Laher
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Exponential Stability for Impulsive BAM Neural Networks with Time-Varying Delays and Reaction-Diffusion Terms

Advances in Difference Equations, 2007
Impulsive bidirectional associative memory neural network model with time-varying delays and reaction-diffusion terms is considered. Several sufficient conditions ensuring the existence, uniqueness, and global exponential stability of equilibrium point ...
Qiankun Song, Jinde Cao
doaj   +2 more sources

Analytic methods for reachability problems

, 2021
We consider a function-analytic approach to study synchronizing automata, primitive and ergodic matrix families. This gives a new way to establish some criteria for primitivity and for ergodicity of families of nonnegative matrices.
PROTASOV, Vladimir
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of a Three-Echelon Supply Chain System with Multiple Retailers, Stochastic Demand and Transportation Times

Mathematics
In this paper we present an exact numerical model for the evaluation of a three-echelon supply chain with multiple retailers. Poisson demand, exponentially distributed transportation times and lost sales at the retailers are assumed.
Georgios Varlas, Stelios Koukoumialos, Alexandros Diamantidis, Evangelos Ioannidis   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source