Results 81 to 90 of about 7,271,767 (336)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

General solution of the Poisson equation for Quasi-Birth-and-Death processes

, 2016
We consider the Poisson equation $(I-P)\boldsymbol{u}=\boldsymbol{g}$, where $P$ is the transition matrix of a Quasi-Birth-and-Death (QBD) process with infinitely many levels, $\bm g$ is a given infinite dimensional vector and $\bm u$ is the unknown. Our
Bini, Dario A., Dendievel, Sarah, Latouche, Guy, Meini, Beatrice   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Space--time fluctuations and the spreading of wavepackets

, 2009
Using a density matrix description in space we study the evolution of wavepackets in a fluctuating space-time background. We assume that space-time fluctuations manifest as classical fluctuations of the metric.
Abel Camacho, Alfredo Macias, Birell N D, Bonifacio Paolo M, Breuer H-P, Claus Lämmerzahl, Ertan Göklü, Göklü E, Hogan C J, Lämmerzahl C Rademaker P, Novikov E A, Novikov E A, Sonego S, Wang C H-T   +13 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Matrix generalizations of some dynamic field theories

, 1995
We introduce matrix generalizations of the Navier--Stokes (NS) equation for fluid flow, and the Kardar--Parisi--Zhang (KPZ) equation for interface growth.
A. Zee, Ala-Nissila, Barabasi, Barma, Bouchaud, Bouchaud, Brézin, Brézin, Brézin, DeDominicis, Deker, Doherty, Forster, Frey, Halpin-Healy, Hooft, Kardar, Kardar, Kardar, Kolmogorov, Kolmogorov, Krug, Lassig, Medina, Mehran Kardar, Mehta, Moore, Mou, Mou, Porter, Schwartz, Sun, Tu, Voiculescu, Yakhot, Zinn-Justin   +35 more
core   +1 more source

Stability of the matrix Dyson equation and random matrices with correlations [PDF]

, 2016
We consider real symmetric or complex hermitian random matrices with correlated entries. We prove local laws for the resolvent and universality of the local eigenvalue statistics in the bulk of the spectrum.
Oskari Ajanki, L. Erdős, Torben Krüger
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

R-matrix for a geodesic flow associated with a new integrable peakon equation

, 2016
We use the r-matrix formulation to show the integrability of geodesic flow on an $N$-dimensional space with coordinates $q_k$, with $k=1,...,N$, equipped with the co-metric $g^{ij}=e^{-|q_i-q_j|}\big(2-e^{-|q_i-q_j|}\big)$.
Holm, Darryl D., Qiao, Zhijun
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source