Results 101 to 110 of about 3,840,303 (366)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Abel-type transformations into ℓ

International Journal of Mathematics and Mathematical Sciences, 1999
Let t be a sequence in (0,1) that converges to 1, and define the Abel-type matrix Aα,t by ank=(k+α     k)tnk+1(1−tn)α+1 for α>−1. The matrix Aα,t determines a sequence-to-sequence variant of the Abel-type power series method of summability introduced by ...
Mulatu Lemma
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Polarimetric Guided Nonlocal Means Covariance Matrix Estimation for Defoliation Mapping [PDF]

, 2020
Jørgen A. Agersborg, Stian Normann Anfinsen, Jane Uhd Jepsen   +2 more
openalex   +1 more source

Term Mapping Using Matrix Operations

, 2008
We believe that gene name identification is a modular process involving term recognition, classification and mapping. This work's focus is on gene name mapping, and we assume that names are already recognized and classified. We use a combination of two methods to map recognized entities to their appropriate gene identifiers (Entrez GeneIDs): the ...
Krauthammer, Michael, Luong, Thaibinh
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Some Tauberian theorems for Euler and Borel summability

International Journal of Mathematics and Mathematical Sciences, 1980
The well-known summability methods of Euler and Borel are studied as mappings from ℓ1 into ℓ1. In this ℓ−ℓ setting, the following Tauberian results are proved: if x is a sequence that is mapped into ℓ1 by the Euler-Knopp method Er with r>0 (or the Borel ...
J. A. Fridy, K. L. Roberts
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Mann iteration and fixed point theorems for multidimensional matrix transforms with asymptotic properties

Journal of Inequalities and Applications
Fixed point theorems for nonexpansive mappings are extended to double sequences using four-dimensional matrix transforms. Asymptotic dominance is introduced to unify iteration schemes, including a Mann iteration for Pringsheim convergence, and asymptotic
Sami M. Hamid, Richard F. Patterson
doaj   +1 more source