Results 91 to 100 of about 1,744,463 (240)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Journal of Inequalities and ApplicationsIn this paper, we introduce the notion of unified interpolative contractions of the Reich–Rus–Ćirić type and give some results about the fixed points for these mappings in the framework of relational metric spaces.
Koti N. V. V. Vara Prasad +4 more
doaj +1 more source
Fine structure of matrix Darboux-Toda integrable mapping
, 2020 The matrix Darboux-Toda mapping is represented as a product of a number of commutative mappings. The matrix Davey-Stewartson hierarchy is invariant with respect to each of these mappings.
E A Yuzbashyan, A N Leznov, A P Fordy
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Matrix $A_p$ weights, degenerate Sobolev spaces, and mappings of finite distortion. [PDF]
, 2016 We study degenerate Sobolev spaces where the degeneracy is controlled by a matrix A_p weight. We prove that the classical Meyers-Serrin theorem, H = W, holds in this setting.
Moen, Kabe
core
Mappings which Preserve Idempotents, Local Automorphisms, and Local Derivations
, 1993 It is proved that linear mappings of matrix algebras which preserve idempotents are Jordan homomorphisms. Applying this theorem we get some results concerning local derivations and local automorphisms.
Matej Brešar, Peter Šemrl
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Some common fixed point theorems for biased mappings [PDF]
, 2000 summary:Some common fixed point theorems in normed spaces are proved using the concept of biased mappings- a generalization of compatible ...
Sahar, Salma, Shahzad, Naseer
core +1 more source