Results 211 to 220 of about 151,446 (258)

Matrix metalloproteinase-2

Annals of the New York Academy of Sciences, 2006
Abstract:  The pathogenesis of abdominal aortic aneurysm (AAAs) involves progressive cycles of proteolysis and inflammation, the product of proteolysis driving subsequent inflammation. Little is yet known about the initiating events. We review the specific literature examining the possibility that MMP‐2 may be the initial catalyst.
Matt, Thompson, Gillian, Cockerill
openaire   +3 more sources

Matrix metalloproteinase‐2 regulates the expression of tissue inhibitor of matrix metalloproteinase‐2

Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura   +9 more
openaire   +2 more sources

Matrix Metalloproteinase-2 in Dentin Matrix Mineralization

Journal of Endodontics, 2001
In the serum-free culture medium of bovine odontoblasts we detected active gelatinolytic metalloproteinases, matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases A and B). The activity of MMP-2, in particular, appeared suddenly around day 21 in the culture, coinciding with the development of odontoblastic cell processes and the loss of alkaline ...
M, Satoyoshi   +6 more
openaire   +2 more sources

Matrix Metalloproteinase 2: Involvement in Keratoconus

European Journal of Ophthalmology, 2000
Purpose The activation of matrix metalloproteinase-2 (MMP-2) is postulated to be a crucial pathogenic factor behind progressive and chronic diseases in which basement membranes are disrupted. An ocular example is keratoconus.
V A, Smith, D L, Easty
openaire   +2 more sources

Matrix metalloproteinases 2 and 9, and extracellular matrix in Kaposi's sarcoma

Dermatologic Therapy, 2010
Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered.
BONGIORNO, Maria Rita   +3 more
openaire   +3 more sources

Mechanisms of cytosolic targeting of matrix metalloproteinase‐2

Journal of Cellular Physiology, 2012
AbstractMatrix metalloproteinase‐2 (MMP‐2) is best understood for its biological actions outside the cell. However, MMP‐2 also localizes to intracellular compartments and the cytosol where it has several substrates, including troponin I (TnI). Despite a growing list of cytosolic substrates, we currently do not know the mechanism(s) that give rise to ...
Mohammad A M, Ali   +7 more
openaire   +2 more sources

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