Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou +7 more
wiley +1 more source
Effects of artificial light with different spectral compositions on refractive development and matrix metalloproteinase 2 and tissue inhibitor of metalloproteinases 2 expression in the sclerae of juvenile guinea pigs. [PDF]
Yuan J +8 more
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Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail. [PDF]
Nezhad NN +4 more
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RETRACTION: Capn4 is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via Nuclear Factor-κB-Induced Matrix Metalloproteinase 2 Expression. [PDF]
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Matrix Metalloproteinase 2 (MMP2)
, 2016Matrix Metalloproteinases (MMPs) are a family of glycoprotein enzymes, which are zinc-dependent endoproteinases. These degradative enzymes digest the blood-vessel walls to allow endothelial cells to escape and migrate toward the site of the angiogenic stimuli. MMPs play a role in angiogenesis in many different ways; endothelial cell migration caused by
A. Salajegheh
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Matrix metalloproteinase 2-responsive micelle for siRNA delivery.
Biomaterials, 2014Systemic delivery of small interfering RNA (siRNA) into cancer cells remains the major obstacle to siRNA drug development. An ideal siRNA delivery vehicle for systemic administration should have long circulation time in blood, accumulate at tumor site, and sufficiently internalize into cancer cells for high-efficiency of gene silence. Herein, we report
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Mechanisms of cytosolic targeting of matrix metalloproteinase‐2
Journal of Cellular Physiology, 2012AbstractMatrix metalloproteinase‐2 (MMP‐2) is best understood for its biological actions outside the cell. However, MMP‐2 also localizes to intracellular compartments and the cytosol where it has several substrates, including troponin I (TnI). Despite a growing list of cytosolic substrates, we currently do not know the mechanism(s) that give rise to ...
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Matrix Metalloproteinase-2 in Dentin Matrix Mineralization
Journal of Endodontics, 2001In the serum-free culture medium of bovine odontoblasts we detected active gelatinolytic metalloproteinases, matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases A and B). The activity of MMP-2, in particular, appeared suddenly around day 21 in the culture, coinciding with the development of odontoblastic cell processes and the loss of alkaline ...
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