Results 341 to 350 of about 794,000 (393)

Matrix metalloproteinase‐2 regulates the expression of tissue inhibitor of matrix metalloproteinase‐2

Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura, Xian Wu, Cheng, Kae, Nakamura, Aiko, Inoue, Lina, Hu, Haizhen, Song, Kenji, Okumura, Akihisa, Iguchi, Toyoaki, Murohara, Masafumi, Kuzuya   +9 more
openaire   +2 more sources

Matrix Metalloproteinase 2: Involvement in Keratoconus

European Journal of Ophthalmology, 2000
Purpose The activation of matrix metalloproteinase-2 (MMP-2) is postulated to be a crucial pathogenic factor behind progressive and chronic diseases in which basement membranes are disrupted. An ocular example is keratoconus. The purpose of the present enquiry was therefore to investigate and compare the activities of the MMP-2 secreted by keratocytes ...
V A, Smith, D L, Easty
openaire   +2 more sources

Neutrophil activator of matrix metalloproteinase-2 (NAM)

Clinical & Experimental Metastasis, 2006
We have isolated a novel soluble factor(s), neutrophil activator of matrix metalloproteinases (NAM), secreted by unstimulated normal human peripheral blood neutrophils that causes the activation of cell secreted promatrix metalloproteinase-2 (proMMP-2).
Ellen E, Rollo, Michelle, Hymowitz, Cathleen E, Schmidt, Steve, Montana, Hussein, Foda, Stanley, Zucker   +5 more
openaire   +2 more sources

Matrix metalloproteinase-2 promoter variability in psoriasis

Archives of Dermatological Research, 2009
The expression of matrix metalloproteinase-2 was observed to be significantly upregulated in psoriasis. The aim of this study was to associate the DNA polymorphic variants in MMP-2 promoter gene with psoriasis and/or with psoriasis phenotypes related to psoriasis and comorbid heredity.
Vladimir, Vasku, Julie, Bienertova Vasku, Veronika, Slonková, Katerina, Kanková, Anna, Vasku   +4 more
openaire   +2 more sources

Matrix metalloproteinases 2 and 9, and extracellular matrix in Kaposi's sarcoma

Dermatologic Therapy, 2010
Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered.
BONGIORNO, Maria Rita, DOUKAKI, Spyridoula, FERRO, Giuseppe, ARICO', Mario   +3 more
openaire   +3 more sources

Serum activity of matrix metalloproteinases-2 and-9

Bulletin of Experimental Biology and Medicine, 2006
Matrix metalloproteinases belong to the key effectors of tissue remodeling in health and disease. Matrix metalloproteinases -2 and -9, the most prevalent representatives of this family, are expressed in the endometrium. Chronic endometritis concomitant with sterility and spontaneous abortions is associated with decreased content of matrix ...
G M, Soboleva, A V, Shurshalina, G T, Sukhikh   +2 more
openaire   +2 more sources

Type I Collagen Stabilization of Matrix Metalloproteinase-2

Archives of Biochemistry and Biophysics, 2001
The activity of matrix metalloproteinase-2 (MMP-2) is regulated stringently on the posttranslational level. MMP-2 efficiently undergoes autolysis into inactive polypeptides in vitro, prompting the hypothesis that MMP-2 autolysis may function as an alternative mechanism for posttranslational control of MMP-2 in vivo. Moreover, MMP-2 binds to intact type
S M, Ellerbroek, Y I, Wu, M S, Stack
openaire   +2 more sources

Matrix metalloproteinase 2 and 9 in esophageal cancer

International Journal of Oncology, 1996
To search for the biochemical properties of esophageal carcinoma relevant to its aggressive behavior, we studied metalloproteinases released from surgical specimens of the carcinoma. In an assay with [H-3]-labeled gelatin, esophageal carcinoma tissues showed gelatinolytic activities clearly higher than those of paired normal mucosae.
M, Kataoka, S, Yamagata, H, Takagi, A, Thant, S, Akiyama, K, Iida, T, Watanabe, S, Saga, J, Kishi, M, Hamaguchi   +9 more
openaire   +2 more sources

Evaluation of matrix metalloproteinase‐2 in lung cancer

PROTEOMICS – Clinical Applications, 2014
PurposeThere is an obvious need to diagnose lung cancer using novel noninvasive and sensitive biomarkers. In this regard, the aim of the present study was to evaluate and compare sputum matrix metalloproteinase 2 (MMP‐2) in relation to serum MMP‐2 of lung cancer patients and other nonmalignant lung diseases in order to establish a new diagnostic and ...
Randa, Ali-Labib, Manal Louis, Louka, Iman Hassan El-Sayed, Galal, Marwa, Tarek   +3 more
openaire   +2 more sources

Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity

Biochemical and Biophysical Research Communications, 2012
Matrix metalloproteinase (MMP)-2 is a zinc-dependent endopeptidase which, alongside its known extracellular actions, plays fundamental roles in oxidative stress-induced injury to the heart. Intracellular cleavage targets of MMP-2 selectively mediating this injury include the sarcomeric proteins troponin I, myosin light chain-1 and titin; some of these ...
Mohammad A M, Ali, Alesandra, Stepanko, Xiaohu, Fan, Andrew, Holt, Richard, Schulz   +4 more
openaire   +2 more sources