Results 41 to 50 of about 19,663,610 (303)

Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1 [PDF]

, 2000
Bachmeier BE, Nerlich AG, Boukamp P, et al. Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1. BIOLOGICAL CHEMISTRY.
Boukamp, P, Tschesche, Harald, Bachmeier, BE, Bachmeier, B. E., Nerlich, A. G., Fink, E., Fritz, H, Fink, E, Fritz, H., Tschesche, H., Lichtinghagen, R., Nerlich, AG, Lichtinghagen, R, Boukamp, P.   +13 more
core   +1 more source

Association of Pentraxin-3, Galectin-3 and Matrix Metalloproteinase-9/Timp-1 with Cardiovascular Risk in Renal Disease Patients

Acta Clinica Croatica, 2017
Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients.
Milica Miljković, Aleksandra Stefanović, Nataša Bogavac-Stanojević, Sanja Simić-Ogrizović, Jerka Dumić, Darko Černe, Zorana Jelić-Ivanović, Jelena Kotur-Stevuljević   +7 more
doaj   +1 more source

Terms of admission to the hospital and performing endovascular procedures in patients with acute myocardial infarction without ST segment elevation in real clinical practice

КардиоСоматика, 2020
Aim. To find out the relationship of the severity of patients condition, with acute myocardial infarction without ST segment elevation (NSTEMI), upon admission to the hospital on the basis of the Global Registry of Acute Coronary Events (GRACE) scale ...
Ionatan R. Rafaeli, Alexandra Iu. Kireeva, Irina E. Chernysheva, Igor Y. Kostyanov, Nino V. Tsereteli, Alexey V. Azarov, Alexandr V. Stepanov, Sergei P. Semitko   +7 more
doaj   +1 more source

MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas [PDF]

, 2004
NoMatrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type to ...
Tijani, S., Jason H. Gill, Martin, Sandie W., Alan J. Mearns, Alan Anthoney, Mearns, A.J., Kirwan, I.G, Anikin, V.A., Anikin, V.A, Gill, J.H, Tijani, S, Loadman, Paul, Anthoney, A, Jill M. Seargent, Sandie W. Martin, Mearns, Alan J., Kirwan, Ian G., Seargent, Jill M., Anthoney, Alan, Loadman, P.M, Seargent, J.M, Mearns, A.J, Anikin, Vladimir A., Ian G. Kirwan, Tijani, Sidiq, Bibby, M.C, Martin, S.W, Sidiq Tijani, Bibby, Michael C., Loadman, Paul M., Gill, Jason H., Michael C. Bibby, Paul M. Loadman, Vladimir A. Anikin   +33 more
core   +1 more source

The Contribution of Serum Anti–cyclic Citrullinated Peptide Antibody and Matrix Metalloproteinase-3 in Predicting the Activity of Rheumatoid Arthritis Disease

مجلة كلية الطب, 2017
Background: Rheumatoid arthritis is an autoimmune disease characterized by chronic synovial inflammation. The insufficient immune clearance of the apoptotic cell results into the formation of anti-cyclic citrullinated peptide antibodies which may play a ...
Aida R. Al-Derzi
doaj   +1 more source

Expression of Matrix Metalloproteinase 3 in Experimental Atherosclerotic Plaques

Journal of Atherosclerosis and Thrombosis, 2001
In atherosclerotic lesions, matrix metalloproteinases produced by foam cells (macrophages) are thought to increase plaque instability, promote plaque rupture, by degradating extracellular matrix. To investigate the relationship between the expression of these proteinases and the histologic appearance of atheromas, immunohistochemical analysis of matrix
Okamoto, Yasuhiro, Satomura, Kimio, Ohsuzu, Fumitaka, Nakamura, Haruo, Takeuchi, Kyoko, Yoshioka, Masahiko   +5 more
openaire   +3 more sources

Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin) [PDF]

Biochemical Journal, 1988
Connective tissue cells synthesize and secrete a group of matrix metalloproteinases (MMPs), all of which are capable of degrading the extracellular-matrix components. One of them, MMP-3 (stromelysin) has been shown to degrade purified basement-membrane components, collagen IV and laminin [Okada, Y., Nagase, H. & Harris, E. D., Jr. (1986) J.
P A, Bejarano, M E, Noelken, K, Suzuki, B G, Hudson, H, Nagase   +4 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

14-3-3  Protein is Detectable in Blood Serum and Fetlock Joint Synovial Fluid of High Performance Horses [PDF]

Iranian Journal of Veterinary Surgery, 2010
Objective: To investigate whether 14-3-3 eta protein is detectable in synovial fluid and blood serum of high performance horses and to study whether any significant correlation between this and matrix metalloproteinase 1 and 3 in horse synovial fluid ...
Kamran Sardari, Claudia Chavez-Munoz, Ruhangiz Kilani, Neil McKenzie, Aziz Ghahary   +4 more
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source