Results 51 to 60 of about 19,663,610 (303)

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Nelson, EL, Nelson, P. J., Schlöndorff, D, C.D. Cohen, D. Schlöndorff, C.M. Klier, Horuk, R, P.J. Nelson, Schlöndorff, D., Klier, C. M., E.L. Nelson, Nelson, PJ, Cohen, CD, Horuk, R., Cohen, C. D., R. Horuk, Klier, CM, Nelson, E. L.   +17 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Association study between matrix metalloproteinase‐3 gene (MMP3) polymorphisms and ankylosing spondylitis susceptibility

Molecular Genetics & Genomic Medicine, 2019
Background Ankylosing spondylitis (AS) is the second most common cause of inflammatory arthritis worldwide affecting the axial skeleton. Single nucleotide polymorphisms (SNPs) of matrix metalloproteinase‐3 (MMP3) in the development of AS has few been ...
Yong Zhu, Shunan Li, Zhi Huang, Wenhua Xing, Feng Li, Yifeng Da, Jianmin Xue, Manglai Li, Ke Sun, Haiyu Jia, Xuejun Yang   +10 more
doaj   +1 more source

Serum and synovial matrix metalloproteinase-3 as markers of disease activity in early rheumatoid arthritis

Egyptian Rheumatology and Rehabilitation, 2016
Background Matrix metalloprotein ase-3 (MMP-3) is one of the MMPs produced in rheumatoid arthritis (RA) joints. Aim The aim of this study was to evaluate serum and synovial fluid (SF) MMP-3 as markers of disease activity in early RA.
Rasha M Fawzy, Yasser A Abdel Hamid, Mona M Albehesy, Rasha F Aboelmaged   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells

Journal of Experimental & Clinical Cancer Research, 2011
Background matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis.
Yang Li, Shen Lizong, Zhang Wenjie, Xu Yong, Xu Hao, Xu Zekuan   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evaluation of the expression of matrix metalloproteinase 9 and neutrophil gelatinase associated lipocalin in serum, urine and tumoral tissues of female dogs suffering from mammary gland tumors [PDF]

, 2013
In human medicine, it has been shown recently that the level of expression of matrix metalloproteinase-9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL) in serum, urine, and breast tissue were significantly increased in patients with breast
Belot, Guillaume
core  

Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]

, 2012
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Notohamiprodjo, Susan, Jaeckel, Carsten, Djafarzadeh, Roghieh, Hofstetter, Monika, Nelson, Peter J., Rieth, Nicole   +5 more
core   +1 more source

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB. [PDF]

PLoS ONE, 2010
Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 ...
Veronika Souslova, Paul A Townsend, Jelena Mann, Chris M van der Loos, Anna Motterle, Fulvio D'Acquisto, Derek A Mann, Shu Ye   +7 more
doaj   +1 more source