Results 211 to 220 of about 386,755 (358)

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

The hemopexin domain of matrix metalloproteinase-9 attenuates lipopolysaccharide-induced interleukin-6 secretion in liver. [PDF]

Sci Rep
Chien YT, Liao YH, Chong XW, Hsu MC, Chiu CH, Huang C.   +5 more
europepmc   +1 more source

Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

Journal of molecular medicine, 2009
V. Catalán, V. Catalán, J. Gómez-Ambrosi, J. Gómez-Ambrosi, Amaia Rodríguez, Amaia Rodríguez, B. Ramírez, B. Ramírez, Camilo Silva, Camilo Silva, F. Rotellar, F. Rotellar, M. Gil, M. Gil, Javier A. Cienfuegos, Javier A. Cienfuegos, J. Salvador, J. Salvador, G. Frühbeck, G. Frühbeck   +19 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase-9 activity. [PDF]

Sci Adv
Legutko D, Bijoch L, Olszak G, Kuźniewska B, Kalita K, Yasuda R, Kaczmarek L, Michaluk P.   +7 more
europepmc   +1 more source

Matrix metalloproteinase 9 modulates collagen matrices and wound repair

Development, 2015
Danny LeBert, J. Squirrell, Julie Rindy, Elizabeth Broadbridge, Yuming Lui, A. Zakrzewska, K. Eliceiri, A. Meijer, A. Huttenlocher   +8 more
semanticscholar   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Targeting Matrix Metalloproteinase-9 to Alleviate T Cell Exhaustion and Improve Sepsis Prognosis. [PDF]

Research (Wash D C)
Wang X, Ning J, Zhou L, Li H, Cui J, Wang J, Liang X, Li J, Li M, Gao X, Li W, Chen X, Yu F, Wei L, Ma C.   +14 more
europepmc   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Comparison of Serum Matrix Metalloproteinase-9 Levels in Diabetic and Non-diabetic Chronic Wounds. [PDF]

Cureus
Joseph J, Chandranaath A, Louis J, Rubby SA, Govindan VK, Veronika M.   +5 more
europepmc   +1 more source