Results 221 to 230 of about 143,801 (262)

“Uncorking” of liposomes by matrix metalloproteinase-9

Chem. Commun., 2005
A triggered release methodology of liposomal contents via the enzyme MMP-9 is described.
Nihar R, Sarkar, Theresa, Rosendahl, Aaron B, Krueger, Abir L, Banerjee, Keith, Benton, Sanku, Mallik, D K, Srivastava   +6 more
openaire   +2 more sources

Matrix Metalloproteinase-9 and Airway Remodeling in Asthma

Current Drug Target -Inflammation & Allergy, 2005
Airway remodeling is a major change responsible for irreversible asthmatic airflow restriction. The Th-2 cytokines-dominant eosinophilic inflammatory mechanism cannot fully explain the progressive subepithelial fibrosis and structural changes in the extracellular matrix (ECM).
Hiroyuki, Ohbayashi, Kaoru, Shimokata
openaire   +2 more sources

The Response of Matrix Metalloproteinase-9 and -2 to Exercise

Sports Medicine, 2014
Matrix metalloproteinases (MMPs) are a major group of enzymes that play essential roles in normal functioning of diverse tissues during growth, development, and aging. However, among the MMPs little is known regarding the role of exercise in MMP-9 and MMP-2 function in humans.The aim of this study was to provide a systematic comprehensive review of the
Dahan da Cunha, Nascimento, Rita de Cassia Marqueti, Durigan, Ramires Alsamir, Tibana, João Luiz Quagliotti, Durigan, James Wilfred, Navalta, Jonato, Prestes   +5 more
openaire   +2 more sources

Matrix metalloproteinase-9 and osteoporosis

2023
Introduction: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes involved in the degradation of extracellular matrix (ECM) components. The overexpression and increased activity of MMPs is observed in many physiological and pathological processes, including estrogen deficiency osteoporosis.
Grigoryan, Armine V., Betova, Tatyana M., Dimitrova, Anelia A., Kostov, Krasimir G., Blazhev, Alexander B.   +4 more
openaire   +1 more source

Matrix Metalloproteinase-9 in Peripheral Blood Eosinophils

International Archives of Allergy and Immunology, 1999
<i>Background:</i> Matrix metalloproteinases (MMPs) are major contributors to tumor invasion, remodeling of connective tissue and infiltration of inflammatory cells and may be important mediators in developing allergic inflammation. Overexpression of MMP-9 mRNA by eosinophils in the asthmatic airways has been reported.
T, Fujisawa, Y, Kato, A, Terada, K, Iguchi, H, Kamiya   +4 more
openaire   +2 more sources

Exhaled Matrix Metalloproteinase-9 in Lung Cancer

Rejuvenation Research, 2012
Background: Matrix metalloproteinase-9 (MMP-9) has been recognized in several types of tumor development and progression, including lung cancer, for its role in the degradation and remodeling of lung tissue. Furthermore, increased MMP-9 has been commonly described in the serum and airways of non-small cell lung ...
CARPAGNANO, GIOVANNA ELISIANA, MARTINELLI, DOMENICO, LACEDONIA, DONATO, FOSCHINO BARBARO, MARIA PIA, Palladino GP, Orlando S   +5 more
openaire   +3 more sources

Suppression of matrix metalloproteinase‐9 by 4‐methylumbelliferone

Cell Biology International, 2007
AbstractOHK cells, a human lymphoma cell line, are known to produce large amounts of hyaluronan. We investigated the effect of 4‐methylumbelliferone, an inhibitor of hyaluronan synthesis, on the activity of matrix metalloproteinases in OHK cells. Matrix metalloproteinase‐9 was detected on gelatin zymography as the main metalloproteinase excreted into ...
Rika, Nakamura, Hiroko, Kuwabara, Masahiko, Yoneda, Shuichi, Yoshihara, Takashi, Ishikawa, Tomisato, Miura, Hiroyuki, Nozaka, Naoki, Nanashima, Tatsusuke, Sato, Toshiya, Nakamura   +9 more
openaire   +2 more sources

Matrix metalloproteinases‐9 in preterm and term human parturition

The Journal of Maternal‐Fetal Medicine, 1999
Spontaneous rupture of the fetal membranes occurs after the commencement of labor in 90% of cases. Recent evidence indicates that the process of parturition requires not only an increase in myometrial contractility and cervical ripening, but also degradation of extracellular matrix in fetal membranes (i.e., leakage of fibronectin into cervico-vaginal ...
ATHAYDE N, ROMERO R, GOMEZ R, MAYMON E, PACORA P, MAZOR M, YOON BH, FORTUNATO S, MENON R, GHEZZI, FABIO, EDWIN S.S.   +10 more
openaire   +3 more sources

Genetic Variants in Matrix Metalloproteinase-9 Gene Modify Metalloproteinase-9 Levels in Black Subjects

DNA and Cell Biology, 2012
Altered matrix metalloproteinases (MMPs) levels are involved in cardiovascular diseases and increased MMP-9 levels enhance the cardiovascular risk in apparently healthy subjects. We investigated the effects of MMP-9 gene polymorphisms and haplotypes on the circulating MMP-9 levels in healthy black subjects and the effects of an MMP-2 polymorphism on ...
Ingrid F, Metzger, Marcelo R, Luizon, Riccardo, Lacchini, Jose Eduardo, Tanus-Santos   +3 more
openaire   +2 more sources

Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma

Annals of Allergy, Asthma & Immunology, 2003
Matrix metalloproteinase-9 (MMP-9) is capable of degrading elastin, whereas tissue inhibitor of metalloproteinase-1 (TIMP-1) can inhibit MMP-9 activity. We observed reduced airway tissue elastin volume density in six subjects with nocturnal asthma (NA) as compared with seven subjects with nonnocturnal asthma (NNA) and seven normal controls (NL) when ...
David N, Pham, Hong Wei, Chu, Richard J, Martin, Monica, Kraft   +3 more
openaire   +2 more sources