Results 241 to 250 of about 386,755 (358)

Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

open access: yesJournal of Neuroscience, 2014
H. Sidhu   +4 more
semanticscholar   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

open access: yesAdvanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin   +12 more
wiley   +1 more source

Levels of matrix metalloproteinase 9 (MMP-9) are elevated in persons with major depressive disorder who have had a recent suicide attempt. [PDF]

open access: yesBrain Behav Immun Health
Dickerson F   +8 more
europepmc   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

open access: yesAdvanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li   +7 more
wiley   +1 more source

Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update

open access: yesAdvanced Science, EarlyView.
This review explores recent advances in the past five years for non‐traditional RAFT polymerization, focusing on new activation strategies, sustainable depolymerization, and integration with automated and AI‐driven synthesis. Together, these innovations advance polymer chemistry and reveal how the pieces of the non‐traditional RAFT puzzle are steadily ...
Vianna F. Jafari   +10 more
wiley   +1 more source

Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.

open access: yesInvestigative Ophthalmology and Visual Science, 2014
R. Kowluru, Julia M. Santos, Qing Zhong
semanticscholar   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

open access: yesAdvanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi   +8 more
wiley   +1 more source

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