Results 271 to 280 of about 237,619 (312)

Matrix Metalloproteinase-9 and Autoimmune Diseases

Journal of Clinical Immunology, 2006
Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodeling. Metalloproteinases also play a
Maya, Ram, Yaniv, Sherer, Yehuda, Shoenfeld   +2 more
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The role of matrix metalloproteinase-9 in dementia

Neuroscience Letters, 2003
Neurofibrillary tangles and senile plaques, constituted of extracellular amyloid deposits (Abeta), are the two defining pathological hallmarks of Alzheimer's disease (AD). Inhibiting the synthesis or aggregation of Abeta or increasing its clearance may reduce the detrimental effects of this peptide and consequently improve cognitive functions in ...
Nicole, Helbecque, Xavier, Hermant, Dominique, Cottel, Philippe, Amouyel   +3 more
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“Uncorking” of liposomes by matrix metalloproteinase-9

Chem. Commun., 2005
A triggered release methodology of liposomal contents via the enzyme MMP-9 is described.
Nihar R, Sarkar, Theresa, Rosendahl, Aaron B, Krueger, Abir L, Banerjee, Keith, Benton, Sanku, Mallik, D K, Srivastava   +6 more
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Matrix Metalloproteinase-9 and Airway Remodeling in Asthma

Current Drug Target -Inflammation & Allergy, 2005
Airway remodeling is a major change responsible for irreversible asthmatic airflow restriction. The Th-2 cytokines-dominant eosinophilic inflammatory mechanism cannot fully explain the progressive subepithelial fibrosis and structural changes in the extracellular matrix (ECM).
Hiroyuki, Ohbayashi, Kaoru, Shimokata
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The Response of Matrix Metalloproteinase-9 and -2 to Exercise

Sports Medicine, 2014
Matrix metalloproteinases (MMPs) are a major group of enzymes that play essential roles in normal functioning of diverse tissues during growth, development, and aging. However, among the MMPs little is known regarding the role of exercise in MMP-9 and MMP-2 function in humans.The aim of this study was to provide a systematic comprehensive review of the
Dahan da Cunha, Nascimento, Rita de Cassia Marqueti, Durigan, Ramires Alsamir, Tibana, João Luiz Quagliotti, Durigan, James Wilfred, Navalta, Jonato, Prestes   +5 more
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Matrix Metalloproteinase-9 in Peripheral Blood Eosinophils

International Archives of Allergy and Immunology, 1999
<i>Background:</i> Matrix metalloproteinases (MMPs) are major contributors to tumor invasion, remodeling of connective tissue and infiltration of inflammatory cells and may be important mediators in developing allergic inflammation. Overexpression of MMP-9 mRNA by eosinophils in the asthmatic airways has been reported.
T, Fujisawa, Y, Kato, A, Terada, K, Iguchi, H, Kamiya   +4 more
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Exhaled Matrix Metalloproteinase-9 in Lung Cancer

Rejuvenation Research, 2012
Background: Matrix metalloproteinase-9 (MMP-9) has been recognized in several types of tumor development and progression, including lung cancer, for its role in the degradation and remodeling of lung tissue. Furthermore, increased MMP-9 has been commonly described in the serum and airways of non-small cell lung ...
CARPAGNANO, GIOVANNA ELISIANA, MARTINELLI, DOMENICO, LACEDONIA, DONATO, FOSCHINO BARBARO, MARIA PIA, Palladino GP, Orlando S   +5 more
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Suppression of matrix metalloproteinase‐9 by 4‐methylumbelliferone

Cell Biology International, 2007
AbstractOHK cells, a human lymphoma cell line, are known to produce large amounts of hyaluronan. We investigated the effect of 4‐methylumbelliferone, an inhibitor of hyaluronan synthesis, on the activity of matrix metalloproteinases in OHK cells. Matrix metalloproteinase‐9 was detected on gelatin zymography as the main metalloproteinase excreted into ...
Rika, Nakamura, Hiroko, Kuwabara, Masahiko, Yoneda, Shuichi, Yoshihara, Takashi, Ishikawa, Tomisato, Miura, Hiroyuki, Nozaka, Naoki, Nanashima, Tatsusuke, Sato, Toshiya, Nakamura   +9 more
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Matrix metalloproteinase-9 and osteoporosis

2023
Introduction: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes involved in the degradation of extracellular matrix (ECM) components. The overexpression and increased activity of MMPs is observed in many physiological and pathological processes, including estrogen deficiency osteoporosis.
Grigoryan, Armine V., Betova, Tatyana M., Dimitrova, Anelia A., Kostov, Krasimir G., Blazhev, Alexander B.   +4 more
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Matrix metalloproteinases‐9 in preterm and term human parturition

The Journal of Maternal‐Fetal Medicine, 1999
Spontaneous rupture of the fetal membranes occurs after the commencement of labor in 90% of cases. Recent evidence indicates that the process of parturition requires not only an increase in myometrial contractility and cervical ripening, but also degradation of extracellular matrix in fetal membranes (i.e., leakage of fibronectin into cervico-vaginal ...
ATHAYDE N, ROMERO R, GOMEZ R, MAYMON E, PACORA P, MAZOR M, YOON BH, FORTUNATO S, MENON R, GHEZZI, FABIO, EDWIN S.S.   +10 more
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