Results 131 to 140 of about 2,395,043 (357)

Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. [PDF]

, 2018
Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2).
Aguayo, Esteban, Baker, Anthony J, Collins, Alexander, Faraji, Farshid, Ge, Liang, Lovett, David H, Ratcliffe, Mark B, Saloner, David, Spaulding, Kimberly, Takaba, Kiyoaki, Wallace, Arthur W, Wang, Guanying   +11 more
core   +2 more sources

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). [PDF]

, 2009
Matrix metalloproteinases (MMPs) have a crucial function in migration of inflammatory cells into the central nervous system (CNS). Levels of MMP-9 are elevated in multiple sclerosis (MS) and predict the occurrence of new active lesions on magnetic ...
Du, Sienmi, Gold, Stefan M, Morales, Laurie B, Sasidhar, Manda V, Sicotte, Nancy L, Tiwari-Woodruff, Seema K, Voskuhl, Rhonda R   +6 more
core   +3 more sources

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

Advanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang   +10 more
wiley   +1 more source

Matrix metalloproteinases and their tissue inhibitors as novel markers in invasive pituitary adenomas – a review

Journal of Education, Health and Sport, 2019
Introduction: Pituitary adenomas are generally benign central nervous system neoplasms with still increasing prevalence, especially in younger people.
Joanna Szydełko, Michał Litwińczuk, Magdalena Szydełko   +2 more
doaj   +1 more source

Distribution of the matrix metalloproteinases stromelysin, gelatinases A and B, and collagenase in Crohn's disease and normal intestine. [PDF]

, 1994
Clifford J. Bailey, Rosalind M. Hembry, A Alexander, M H Irving, Michael E. Grant, C. Adrian Shuttleworth   +5 more
openalex   +1 more source

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty. [PDF]

, 2019
PurposeMatrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring
Chan, Matilda F, Clay, Selene M, Hwang, David G, Oldenburg, Catherine E, Rose-Nussbaumer, Jennifer, Wolf, Marie   +5 more
core  

The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice [PDF]

, 2007
Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target.
Adriana Albini, Aggarwal BB, Aggarwal S, Airola K, Albini A, Albini A, Ammon HP, Andreas Nerlich, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Bachmeier BE, Balduyck M, Banerji A, Beatrice Bachmeier, Benbow U, Benbow U, Bharti AC, Biswas DK, Cailleau R, Cailleau R, Chen H, Chen Z, Commandeur JN, Cristina Iancu, Divya CS, Erwin Schleicher, Garg A, Hahm ER, Hong JH, Hozumi A, Huang MT, Hunter KW, Ichiki K, Kawamori T, Kossakowska AE, Kuo ML, Li L, Limtrakul P, Manna SK, Marianne Jochum, Meade-Tollin LC, Mehta K, Menon LG, Menon LG, Michele Cilli, Mukaida N, Nagabhushan M, Nakshatri H, Netzker R, Noel A, Ohashi Y, Park AM, Park CH, Philip S, Raffaella Dell'Eva, Roberta Vené, Shao ZM, Stetler-Stevenson WG, Tetu B, Ulrich Pfeffer, Vincenti MP, Vincenti MP, Vincenti MP, Westermarck J, Wu JT, Yu G, Zhang RD   +70 more
core   +1 more source

A Novel Core–Shell Hydrogel 3D Model for Studying Macrophage Mechanosensing and Foreign Body Giant Cell Formation

Advanced Healthcare Materials, EarlyView.
The foreign body response (FBR) to biomaterials is primarily driven by macrophages, which often fuse into destructive foreign body giant cells (FBGCs). To address the limited understanding of FBGC formation, a novel microscale core–shell hydrogel 3D model is developed using heterogeneous alginate‐collagen microcapsules with varying stiffness, offering ...
Manisha Mahanty, Wenquan Ou, Xiaoping Zhu, Jonathan S Bromberg, Xiaoming He, Shaik O. Rahaman   +5 more
wiley   +1 more source

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases. [PDF]

, 1993
F. Xavier Gomis‐Rüth, Lawrence F. Kress, Wolfram Bode   +2 more
openalex   +1 more source