Results 111 to 120 of about 273,325 (293)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Matrix Metalloproteinases and Temporomandibular Joint Disorder: A Review of the Literature [PDF]

, 2019
Temporomandibular disorders (TMD) are progressive degenerative disorders that affect the components of the temporomandibular joint (TMJ), characterized by pain and limitations in function.
Almeida, Luis Eduardo, Camejo, Flavio, Haxhia, Ardit, Herm, Logan, Tayebi, Lobat   +4 more
core   +1 more source

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Metalloproteinases and their Inhibitors under the Course of Immunostimulation by CPG-ODN and Specific Antigen Inhalation in Equine Asthma [PDF]

, 2019
Objectives. Inhalation of immunostimulatory bacterial DNA segments (cytosine-phosphate-guanosine-oligodeoxynucleotides, CpG-ODN) normalizes clinical and cytologic parameters in severe equine asthma.
Barton, Ann Kristin, Einspanier, Ralf, Gehlen, Heidrun, Geis, Sabine, Klier, John, Shety, Tarek   +5 more
core   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon [PDF]

, 2006
To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs), and ADAM genes 8, 10, 12, and 17 in normal, painful, and ruptured ...
Alfredson, Alfredson, Amour, Amour, Anthony N. Corps, Archambault, Arnoczky, Asakura, Astrom, Baker, BenEzra, Bjur, Black, Brew, Brian L. Hazleman, Caroline J. Pennington, Cawston, Clancy, Conover, Dickinson, Drummond, Dylan R. Edwards, Fenwick, Gavin C. Jones, Graham P. Riley, Hannafin, Hashimoto, Hieta, Ian M. Clark, Iba, Iba, Ireland, Jarvinen, Jones, Jozsa, Kannus, Kashiwagi, Kashiwagi, Killar, Kurisaki, Lavagnino, Lo, Loechel, Ma, Majima, Malfait, Michelle M. Bradley, Movin, Mueller, Muller, Nakamura, Nuttall, Pei, Pendas, Porter, Primakoff, Rees, Riley, Riley, Riley, Roy, Sandy, Sandy, Sedlacek, Somerville, Sternlicht, Thodeti, Tipton, Tsuzaki, Van Meurs, Van Meurs, Velasco, Yasuda, Yu   +73 more
core   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

Matrix Metalloproteinases [PDF]

Circulation Research, 2002
The matrix metalloproteinases (MMPs) are a family of enzymes (25 identified to date) that have in common the ability to degrade many molecules of the extracellular matrix. MMP activity can be inhibited by the endogenous tissue inhibitors of metalloproteinases (TIMPs 1 through 4), and the net proteolytic activity within a tissue is a function of the ...
openaire   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source