Results 141 to 150 of about 2,315,187 (340)

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Is there new hope for therapeutic matrix metalloproteinase inhibition?

Nature reviews. Drug discovery, 2014
R. Vandenbroucke, C. Libert
semanticscholar   +1 more source

Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins

, 2018
Sarah A. Hibbert, Rachel Watson, C.E.M. Griffiths, Neil K. Gibbs, Michael J. Sherratt   +4 more
openalex   +1 more source

Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes Requires Janus Kinase/STAT Signaling Pathway [PDF]

, 2001
Wenqing Li, Faramaze Dehnade, Muhammad Zafarullah   +2 more
openalex   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Matrix metalloproteinase interactions with collagen and elastin

Matrix Biology, 2015
S. V. Van Doren
semanticscholar   +1 more source

Serum matrix metalloproteinase‐3 concentration is influenced by MMP‐3 −1612 5A/6A promoter genotype and associated with myocardial infarction [PDF]

, 2005
Ann Samnegård, Angela Silveira, Pia Lundman, Susanna Boquist, Jacob Odeberg, J. Hulthe, William L. McPheat, Per Tornvall, L. Bergstrand, Christer Ericsson, Anders Hamsten, Per Eriksson   +11 more
openalex   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics

Proceedings of the National Academy of Sciences of the United States of America, 2003
M. Lutolf, Janelle L. Lauer-Fields, H. Schmoekel, A. Metters, F. Weber, G. Fields, J. Hubbell   +6 more
semanticscholar   +1 more source