Results 151 to 160 of about 2,315,187 (340)

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Matrix Metalloproteinase Inhibition in Melanoma. [PDF]

Exp Dermatol
Zhang E, Thakur V, Bedogni B.
europepmc   +1 more source

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

Proceedings of the National Academy of Sciences of the United States of America, 1990
H. E. Wart, Henning BIRKEDAL-HANSENt
semanticscholar   +1 more source

Design and Synthesis of Matrix Metalloproteinase Inhibitors Guided by Molecular Modeling. Picking the S₁Pocket Using Conformationally Constrained Inhibitors

, 2001
Stephen Hanessian, D. Mackay, Nicolas Moitessier   +2 more
openalex   +1 more source

Overexpression of Urokinase by Plaque Macrophages Causes Histological Features of Plaque Rupture and Increases Vascular Matrix Metalloproteinase Activity in Aged Apolipoprotein E–Null Mice [PDF]

, 2010
Jie Hu, Liang Du, Talyn Chu, Goro Otsuka, Nagadhara Dronadula, Mia Jaffe, Sean E. Gill, William C. Parks, David A. Dichek   +8 more
openalex   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Characterization of a cis-regulatory element upstream of matrix metalloproteinase-9. [PDF]

Sci Rep
Rangaraj A, Kaur H, Mejia L, Hansen J, Biswas A, Tuteja G.   +5 more
europepmc   +1 more source

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

Cell, 1996
P. Brooks, S. Strömblad, L. C. Sanders, T. V. Schalscha, R. Aimes, W. Stetler-Stevenson, J. Quigley, D. Cheresh   +7 more
semanticscholar   +1 more source

Matrix metalloproteinase expression and activity in human airway smooth muscle cells [PDF]

, 2004
Shona R. Elshaw, Neil C. Henderson, Alan J. Knox, Susan A. Watson, David J. Buttle, Simon R. Johnson   +5 more
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source