Results 191 to 200 of about 75,485,891 (288)

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Exploring the Genetic Role of Matrix Metalloproteinase-13 Variants in Pterygium Risk. [PDF]

In Vivo
Chen HC, Hsia NY, Hu PS, Hsia TC, Wang YC, Shih HY, Chang WS, Bau DT, Tsai CW.   +8 more
europepmc   +1 more source

Pre-Clinical Study: Immunohistochemical evaluation of matrix metalloproteinase-13 on rabbit ( Oryctolagus cuniculus) socket healing after application of platelet-rich fibrin with and without hydroxyapatite. [PDF]

F1000Res, 2022
Damayanti MM, Rachmawati M.
europepmc   +1 more source

The role of matrix metalloproteinase-13 in the regression of liver fibrosis [PDF]

, 2007
The specific aims of this study were i) to determine the relative expression of MMP-13 in the regression of experimental live fibrosis; ii) to determine the cellular source of MMP-13 in resolving liver fibrosis; iii) to determine, mechanistically, the importance of MMP-13 in mediating regression of liver fibrosis.
openaire  

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Effects of Acupuncture at ST36 and SP6 on Activity Levels and Pain Thresholds Through Interleukin-1, Interleukin-6, Cortisol, and Matrix Metalloproteinase-13 Modulation in an Osteoarthritis Rat Model. [PDF]

J Pharmacopuncture
Wulandari M, Handono K, Khotimah H, Yuliatun L.   +3 more
europepmc   +1 more source

Risk Factors for Pulmonary Metastasis in Differentiated Thyroid Carcinoma Patients and the Significance of Changes in Matrix Metalloproteinase 13 and microRNA-142 Levels.

Contrast Media Mol Imaging, 2022
Zhang X, Lu Z, Zhang G, Li S, Zhao A, Miao Y, Wang W.   +6 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Matrix metalloproteinase 13 (MMP-13) processing of type II collagen is altered by antibodies and citrullination found in the early stages of rheumatoid arthritis. [PDF]

Matrix Biol
Knapinska AM, Tokmina-Roszyk D, Haag S, Lauer-Fields JK, Singh C, Stawikowska R, He Y, Askling J, Holmdahl R, Fields GB.   +9 more
europepmc   +1 more source