Results 241 to 250 of about 75,485,891 (288)

Persistent magnetic resonance imaging‐derived static anterior tibial translation after anterior cruciate ligament reconstruction is associated with elevated cartilage T2 relaxation times but not serum biomarkers

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Persistent, static anterior tibial translation (sATT) alterations following anterior cruciate ligament reconstruction (ACLR) may influence cartilage health. T2 relaxation times and serum biomarkers of cartilage degradation/bone resorption provide insight into osteoarthritis development.
Manuel Angel Romero‐Padron, Tyler Kallman, Mark Amirtharaj, Neal Weldon, Melissa Manzer, Balasrinivasa Rao Sajja, Matthew Alan Tao, Elizabeth Wellsandt   +7 more
wiley   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Metabolic‐Epigenetic Coupling in Aortic Aneurysm and Aortic Dissection: GLS1 and SLC1A5 as Guardians of VSMC Homeostasis

iNew Medicine, EarlyView.
Yu Zeng, Jifeng Zhang, Haocheng Lu
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Mapping Tumor Recurrence and Metastasis With Pan‐Cancer Multi‐Omics

Med Research, EarlyView.
Tumor recurrence and metastasis arise from the interaction of shared evolutionary programs and context‐dependent modifiers. Clonal evolution, including genomic instability, subclonal selection, and treatment pressure, interacts with reversible cell‐state plasticity involving partial EMT, stemness, and dormancy, whereas immune escape, stromal remodeling,
Wenjun Meng, Ruicen Li, Xiaoli Mu, Xiaolong Tang, Yuxi Luo, Yingying Lei, Jinghong Xian, Guiyi Ji, Yihao Liu, Chenyu Huo, Sihan Li, Yalun Li, Jiadi Gan, Weimin Li   +13 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Genska ekspresija matriks metaloproteinaze 2, matriks metaloproteinaze 13, te tkivnog inhibitora matriks metaloproteinaze-1 u epitelu oboljelih ljudskih rožnica

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 2016
Dekaris, Iva, Sobočanec, Sandra, Korolija, Marina, Mačak-Šafranko, Željka, Dukić, Adrijana, Balog, Tihomir   +5 more
openaire   +1 more source

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Increased Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9 and Matrix Metalloproteinase-13 in Lesional Skin of Bullous Pemphigoid

International Archives of Allergy and Immunology, 2006
<i>Background:</i> Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. <i>Objective:</i> To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the ...
Yayoi, Niimi, Ruby, Pawankar, Seiji, Kawana   +2 more
openaire   +2 more sources