Results 251 to 260 of about 75,485,891 (288)
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Immunohistochemical Expression of Matrix Metalloproteinase 13 in Chronic Periodontitis
International Journal of Periodontics & Restorative Dentistry, 2014The extracellular matrix is a complex integrated system responsible for the physiologic properties of connective tissue. Collagen is the major extracellular component that is altered in pathologic conditions, mainly periodontitis. The destruction involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs), which play a key role in ...
Alapati, Nagasupriya +5 more
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The Structure, Regulation, and Function of Human Matrix Metalloproteinase-13
Critical Reviews in Biochemistry and Molecular Biology, 2002Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis.
Matthew F, Leeman +2 more
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Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13
Current Pharmaceutical Biotechnology, 2008The role of matrix metalloproteinases in disease has been investigated over the last two decades. A focus on this family of proteases is particularly emphasized in two major arthritides in humans, osteoarthritis and rheumatoid arthritis. Early work described the presence of multiple MMP family members in the joint of the disease state and recent ...
Hironari, Takaishi +4 more
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Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13
Journal of Medicinal Chemistry, 2011Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a potent, selective MMP-13 inhibitor, developed using fragment-based structure-guided lead ...
Taylor, Steven J. +18 more
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American Journal of Veterinary Research, 2001
Abstract Objectives—To determine collagenase activity and evaluate matrix metalloproteinase (MMP)-8 and MMP-13 in horses with chronic obstructive pulmonary disease (COPD). Animals—12 horses with COPD and 12 healthy control horses. Procedure—Collagenase activity was determined by use of an assay for degradation of type-I ...
S M, Raulo +3 more
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Abstract Objectives—To determine collagenase activity and evaluate matrix metalloproteinase (MMP)-8 and MMP-13 in horses with chronic obstructive pulmonary disease (COPD). Animals—12 horses with COPD and 12 healthy control horses. Procedure—Collagenase activity was determined by use of an assay for degradation of type-I ...
S M, Raulo +3 more
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Journal of Hepatology, 1999
Matrix metalloproteinase-13, one of the principal neutral proteinases capable of cleaving native fibrillar collagens, is important in the degradation and remodeling of extracellular matrix. However, its precise expression in liver injury has not been characterized. We examined the kinetics of the expression of matrix metalloproteinase-13 and one of its
Y, Yata +4 more
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Matrix metalloproteinase-13, one of the principal neutral proteinases capable of cleaving native fibrillar collagens, is important in the degradation and remodeling of extracellular matrix. However, its precise expression in liver injury has not been characterized. We examined the kinetics of the expression of matrix metalloproteinase-13 and one of its
Y, Yata +4 more
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Expression of matrix metalloproteinase-13 (MMP-13) in the testes of growing and adult chicken
Acta Histochemica, 2013Although several matrix metalloproteinases (MMPs) have been implicated in testis development, the presence of MMP-13 protein has not been directly substantiated in the male avian gonads. In this study, we examined the expression patterns of MMP-13 and MMP inhibitors, TIMP-1 and TIMP-2, in immature (4weeks), pre-pubertal (16weeks), and mature (1year ...
Man-Il, Huh, Jae-Chang, Jung
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Regulation of matrix metalloproteinase 13 expression by androgen in prostate cancer
Oncology Reports, 2004The matrix metalloproteinases (MMPs) are members of a family of endopeptidases that are able to degrade extra-cellular matrix. MMPs and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), play a key role in the migration of normal and malignant cell.
Pang, See Tong +5 more
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Serum levels of matrix metalloproteinase‐13 in patients with eosinophilic fasciitis
The Journal of Dermatology, 2014AbstractMatrix metalloproteinase‐13 (MMP‐13), a member of the collagenase family, has been implicated in the pathogenesis of connective tissue diseases characterized by extracellular matrix remodeling. Since serum MMP‐13 levels reflect disease severity of systemic sclerosis and localized scleroderma, we evaluated the clinical significance of serum MMP ...
Yoshihide, Asano +5 more
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Elevated Expression of Matrix Metalloproteinase-13 in Abdominal Aortic Aneurysms
Annals of Vascular Surgery, 2004Destructive remodeling of extracellular matrix has been shown to be present in aneurysmal abdominal aorta. We used real-time quantitative reverse transcriptase polymerase chain reaction to determine the relative expression of matrix metalloproteinase-13 (MMP13) in aortic tissue samples from patients who underwent abdominal aortic aneurysm repair ...
Gerard, Tromp +6 more
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