Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression [PDF]
, 2023 三重大学博士(医学)application/pdfIdiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis.Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis.
井上, 亮 +2 more
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New insights into the role of matrix metalloproteinase 3 (MMP3) in bone
FASEB BioAdvances, 2022 The Matrix Metalloproteinases are important regulators of bone metabolism and can influence bone mass and bone remodeling. We investigate the role of Matrix Metalloproteinase 3 (MMP3) on bone in mice, by using Mmp3 knockout (Mmp3 KO) in the context of ...
Frédéric Jehan +6 more
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Matrix metalloproteinase-3 in brain physiology and neurodegeneration [PDF]
Advances in Clinical and Experimental Medicine, 2019 Structural and functional synapse reorganization is one of the key issues of learning and memory mechanisms. Specific proteases, called matrix metalloproteinases (MMPs), play a pivotal role during learning-related modification of neural circuits. Different types of MMPs modify the extracellular perisynaptic environment, leading to the plastic changes ...
Anna Maria Lech +2 more
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Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer. [PDF]
PLoS ONE, 2015 The main objective of this study was to assess the in vitro effects of curcuminoids extract, hydrolyzed collagen and green tea extract in normal bovine chondrocytes and osteoarthritic human chondrocytes cultured in monolayer. This study also investigated
Fanny Comblain +5 more
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Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]
, 2011 Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Kolev, Kraszimir +5 more
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Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]
, 2011 Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller +9 more
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Neural Regeneration Research, 2015 Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis.
Jun-peng Liu +4 more
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Osteopontin, a Novel Substrate for Matrix Metalloproteinase-3 (Stromelysin-1) and Matrix Metalloproteinase-7 (Matrilysin) [PDF]
Journal of Biological Chemistry, 2001 Osteopontin (OPN) is a secreted phosphoprotein shown to function in wound healing, inflammation, and tumor progression. Expression of OPN is often co-localized with members of the matrix metalloproteinase (MMP) family. We report that OPN is a novel substrate for two MMPs, MMP-3 (stromelysin-1) and MMP-7 (matrilysin).
R, Agnihotri +5 more
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Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Fink, E. +9 more
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Modulation of plasma matrix metalloproteinase 9 and its inhibitors by vitamin D. [PDF]
, 2012 PhDMatrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are upregulated in a variety of diseases. Hypothesis: As TIMP-1 levels are elevated in liver fibrosis, might a similar process occur in essential hypertension driven left ...
Timms, Peter McLean
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