Results 21 to 30 of about 19,511,098 (262)

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

Journal of Biological Chemistry, 1992
Matrix metalloproteinase 9 (MMP-9), also known as 92-kDa gelatinase/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells in zymogen form. Here we report that matrix metalloproteinase 3 (MMP-3/stromelysin) is an activator of the precursor of matrix metalloproteinase 9 (proMMP-9).
Ogata, Y, Enghild, J J; id_orcid 0000-0001-9292-9172, Nagase, H   +2 more
openaire   +3 more sources

Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]

, 2009
Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Braun, Thomas, Besig, Sophie, Baur, Dorothee M., Prinz, Christian, Rad, Roland, Hoefler, Heinz, Höfler, Heinz, Voland, Petra, Perren, Aurel, Langer, Rupert, Voland, P;Besig, S;Rad, R;Braun, T;Baur, DM;Perren, A;Langer, R;Höfler, H;Prinz, C, Voland, Petra;Besig, Sophie;Rad, Roland;Braun, Thomas;Baur, Dorothee M.;Perren, Aurel;Langer, Rupert;Höfler, Heinz;Prinz, Christian   +11 more
core   +2 more sources

Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]

, 2006
Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Helmut Kolb, Krell, Hans-Willi, Kolb, Helmut, Heidinger, Michael, Michael Heidinger, Hans-Willi Krell, Marianne Jochum, Jochum, Marianne, Christian Ries, Ries, Christian   +9 more
core   +1 more source

Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women [PDF]

, 2009
OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and
Lowe, Gordon, Welsh, P, Thomson, A., Jefferis, B. J., Lennon, L., Lowe, G., Ebrahim, S, Carson, Claire, Jefferis, B.J., Welsh, Paul, Rumley, A., Ebrahim, S., Ebrahim, Shah, Jefferis, Barbara J, Lawlor, Debbie, Jefferis, BJ, Welsh, P., Whincup, Peter, Wannamethee, G, Lawlor, D., Lawlor, D, Wannamethee, G., Rumley, Ann, Whincup, P., Whincup, P, Thomson, Andy, Jefferis, Barbara J., Thomson, A, Lennon, Lucy, Wannamethee, Goya, Carson, C., Rumley, A, Lennon, L, Carson, C, Lowe, G   +34 more
core   +1 more source

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]

, 2007
MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Mentele, Reinhard, Egea, Virginia, Jochum, Marianne, Ries, Christian, Zahler, Stefan, Nagase, Hideaki, Pitsch, Thomas   +6 more
core   +1 more source

A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability

Cell Transplantation, 2019
Emerging evidence demonstrates that dysregulation of circular RNA is linked to tumorigenesis and aggressive progression. However, its role in oral squamous cell carcinoma remains largely uncharacterized.
Bing Xia, Tao Hong, Xin He, Xinlan Hu, Yongbo Gao   +4 more
doaj   +1 more source

CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts

Arthritis Research & Therapy, 2017
Background Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage, synovium, and subchondral bone and is the leading cause of disability in older populations.
Sheng-Mou Hou, Chun-Han Hou, Ju-Fang Liu
doaj   +1 more source

Relationship of matrix metalloproteinase-3 -11715A/6A polymorphism (rs35068180) and dilated cardiomyopathy

Российский кардиологический журнал, 2020
Aim. To study the relationship of matrix metalloproteinase-3 (MMP3) genetic polymorphism and dilated ischemic cardiomyopathy (DCM), as well as idiopathic cardiomyopathy (ICM) of unknown etiology.Material and methods.
S. Yu. Nikulina, O. O. Kuznecova, A. A. Chernova, V. N. Maksimov   +3 more
doaj   +1 more source

Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To explore glucose metabolism in rheumatoid arthritis (RA) and its association with insulin resistance (IR) risk factors and disease activity indicators, including matrix metalloproteinase-3 (MMP3). Methods This single-center study included 127
Gorica G. Ristić, Vesna Subota, Dejana Stanisavljević, Danilo Vojvodić, Arsen D. Ristić, Branislava Glišić, Milan Petronijević, Dušan Z. Stefanović   +7 more
doaj   +1 more source

Association of polymorphism -1171 5A/6A of the matrix metalloproteinase gene type 3 (rs35068180) with dilated cardiomyopathy

КардиоСоматика, 2020
The paper describes the investigation of matrix metalloproteinase type 3 (MMP-3) -1171 5A/6A gene polymorphic alleles variants (rs35068180) in patients with dilated cardiomyopathy.
Oxana O. Kuznetsova, Svetlana Yu. Nikulina, Anna A. Chernova, Vladimir N. Maksimov   +3 more
doaj   +1 more source