Results 71 to 80 of about 99,179 (264)

LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]

, 2016
A
Bachert, Claus, Claeys, Cindy, Holtappels, Gabriële, Perez Novo, Claudina, Pezato, Rogerio   +4 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease activity and structural damage

Biomedical Papers, 2017
Aims: To evaluate the serum levels of matrix metalloproteinase-3 (MMP-3) as a potential marker of disease activity and joint damage in 92 patients with rheumatoid arthritis (RA), compared to 24 osteoarthritis (OA) patients and 26 healthy controls ...
Martina Skacelova, Zuzana Hermanova, Pavel Horak, Ahmed Kazi, Katerina Langova   +4 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress. [PDF]

PLoS ONE, 2014
In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death.
Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Kim   +5 more
doaj   +1 more source

Evaluation of MMP‑2, MMP‑9, TIMP‑1, TIMP‑2, NGAL and MMP‑9/NGAL complex in urine and sera from patients with bladder cancer [PDF]

, 2015
The identification of biomarkers in urine or serum samples from patients with bladder cancer is urgently required for the development of non-invasive methods for the diagnosis of bladder carcinoma and to facilitate follow-up surveillance, to combat the ...
Bruzzese, Dario, DI CARLO, Angelina, Ricci, Serena   +2 more
core   +1 more source

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium [PDF]

Arthritis & Rheumatism, 1997
AbstractObjective. To show the eventual presence and extent of production of matrix metalloproteinase 13 (MMP‐13, or collagenase 3) in rheumatoid synovial tissue samples and extracts, and to assess the inhibition characteristics of recombinant MMP‐13.Methods.
O, Lindy, Y T, Konttinen, T, Sorsa, Y, Ding, S, Santavirta, A, Ceponis, C, López-Otín   +6 more
openaire   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Serum and synovial matrix metalloproteinase-3 as markers of disease activity in early rheumatoid arthritis

Egyptian Rheumatology and Rehabilitation, 2016
Background Matrix metalloprotein ase-3 (MMP-3) is one of the MMPs produced in rheumatoid arthritis (RA) joints. Aim The aim of this study was to evaluate serum and synovial fluid (SF) MMP-3 as markers of disease activity in early RA.
Rasha M Fawzy, Yasser A Abdel Hamid, Mona M Albehesy, Rasha F Aboelmaged   +3 more
doaj   +1 more source

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis [PDF]

The American Journal of Pathology, 2011
Idiopathic pulmonary fibrosis (IPF) may be triggered by epithelial injury that results in aberrant production of growth factors, cytokines, and proteinases, leading to proliferation of myofibroblasts, excess deposition of collagen, and destruction of the lung architecture. The precise mechanisms and key signaling mediators responsible for this aberrant
Cory M, Yamashita, Lior, Dolgonos, Rachel L, Zemans, Scott K, Young, Jennifer, Robertson, Natalie, Briones, Tomoko, Suzuki, Megan N, Campbell, Jack, Gauldie, Derek C, Radisky, David W H, Riches, Guoying, Yu, Naftali, Kaminski, Christopher A G, McCulloch, Gregory P, Downey   +14 more
openaire   +2 more sources