Results 41 to 50 of about 156,159 (310)

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer

Biomedicines, 2023
Introduction: Urinary bladder cancer is a serious oncological problem that is the cause of many deaths worldwide. The processes of metastasis and origination of local tumor invasion depend on the extracellular matrix (ECM) degradation.
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chłosta, Marta Bruczko-Goralewska, Przemysław Mitura, Grzegorz Młynarczyk   +7 more
doaj   +1 more source

The calpastatin-derived calpain inhibitor CP1B reduces mRNA expression of matrix metalloproteinase-2 and-9 and invasion by leukemic THP-1 cells [PDF]

, 2003
The ubiquitous proteases μ- and m-calpain are Ca2+-dependent cysteine endopeptidases. Besides involvement in a variety of physio(patho)logical processes, recent studies suggest a pivotal role of calpains in differentiation of hematopoietic cells and ...
Ries, C., Gil-Parrado, S., Jochum, M., Heidinger, M., Ruiz-Heinrich, L., Popp, O.   +5 more
core   +1 more source

Matrix metalloproteinase 9 polymorphism and outcome after myocardial infarction

Cardiogenetics, 2011
Matrix metalloproteinase 9 (MMP9) is functionally implicated in the process of infarct healing. Several genetic variation of the MMP9 gene have been described, among which the MMP9 Arg668Gln polymorphism.
Sophie Rodius, Guillermo Mulliert, Francisco Azuaje, Yvan Devaux, Daniel R. Wagner   +4 more
doaj   +1 more source

Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women

, 2009
OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and
Lowe, Gordon, Welsh, P, Thomson, A., Jefferis, B. J., Lennon, L., Lowe, G., Ebrahim, S, Carson, Claire, Jefferis, B.J., Welsh, Paul, Rumley, A., Ebrahim, S., Ebrahim, Shah, Jefferis, Barbara J, Lawlor, Debbie, Jefferis, BJ, Welsh, P., Whincup, Peter, Wannamethee, G, Lawlor, D., Lawlor, D, Wannamethee, G., Rumley, Ann, Whincup, P., Whincup, P, Thomson, Andy, Jefferis, Barbara J., Thomson, A, Lennon, Lucy, Wannamethee, Goya, Carson, C., Rumley, A, Lennon, L, Carson, C, Lowe, G   +34 more
core   +1 more source

Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9

Matrix Biology, 2023
Extracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments.
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney   +9 more
openaire   +2 more sources

Chitinase-3 like-protein-1, matrix metalloproteinase -9 and positive intracranial arterial remodelling

Frontiers in Aging Neuroscience, 2023
IntroductionPositive intracranial arterial remodelling is a dilated lesion of the large intracranial vessels; however, its pathogenesis is currently unknown.
Ming Tang, Dongyang Zhou, Junhui He, Hongying Bai, Qianqian Li, Hui Xu   +5 more
doaj   +1 more source

Ras, metastasis, and matrix metalloproteinase 9

, 2001
Publisher Summary This chapter describes the Ras, metastasis, and matrix metalloproteinase 9. The process of metastasis involves breakdown and penetration of intercellular matrix and basement membranes. The basement membrane in particular is a barrier to tumor invasion, intravasation, and extravasation.
Bernhard, E, Muschel, R
openaire   +3 more sources

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

Journal of Biological Chemistry, 1992
Matrix metalloproteinase 9 (MMP-9), also known as 92-kDa gelatinase/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells in zymogen form. Here we report that matrix metalloproteinase 3 (MMP-3/stromelysin) is an activator of the precursor of matrix metalloproteinase 9 (proMMP-9).
Ogata, Y, Enghild, J J; id_orcid 0000-0001-9292-9172, Nagase, H   +2 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Assessment of Matrix Metalloproteinases a Prognostic Indicator in Advanced Fibrotic Lung Disease: A Systematic Review

Pakistan Journal of Medicine and Dentistry
Background: Fibrotic lung diseases were seen to have devastating effects among patients globally. Matrix metalloproteinases (MMP) including MMP-7, MMP-9, and MMP-1 have become promising biomarkers for idiopathic pulmonary fibrosis (IPF), and other ...
Mehvish Aqil, Saif Ur Rahman, Muhammad Zeeshan Aslam, Mostafa Ahmed Abdellah Ahmed, Ammar Ahmed, Sidra Javaid, Ehsan Ul Haq   +6 more
doaj   +1 more source