Results 41 to 50 of about 140,703 (263)

Matrix metalloproteinase 9 polymorphism and outcome after myocardial infarction

Cardiogenetics, 2011
Matrix metalloproteinase 9 (MMP9) is functionally implicated in the process of infarct healing. Several genetic variation of the MMP9 gene have been described, among which the MMP9 Arg668Gln polymorphism.
Sophie Rodius, Guillermo Mulliert, Francisco Azuaje, Yvan Devaux, Daniel R. Wagner   +4 more
doaj   +1 more source

Matrix Metalloproteinase-3 but Not Matrix Metalloproteinase-9, Implicated in the Manifestation of Chronic Periodontitis

Reports of Biochemistry and Molecular Biology, 2023
Periodontal disease is an inflammatory condition affecting the tooth's supporting tissues, resulting in gradual loss of periodontal ligament (PDL), alveolar bone, and gum resorption. Neutrophil and monocyte/macrophage, destructive proteases like matrix metalloproteinase (MMP)-3 and MMP-9 play pivotal roles in such lesions in periodontitis.
Pouyan, Razavi, Seyed Abdolrahim, Rezaee, Salehe, Akhondian, Nastaran, Asgari, Kazem, Fatemi, Farnaz, Mohajertehran   +5 more
openaire   +2 more sources

Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9

Matrix Biology, 2023
Extracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments.
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney   +9 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Assessment of Matrix Metalloproteinases a Prognostic Indicator in Advanced Fibrotic Lung Disease: A Systematic Review

Pakistan Journal of Medicine and Dentistry
Background: Fibrotic lung diseases were seen to have devastating effects among patients globally. Matrix metalloproteinases (MMP) including MMP-7, MMP-9, and MMP-1 have become promising biomarkers for idiopathic pulmonary fibrosis (IPF), and other ...
Mehvish Aqil, Saif Ur Rahman, Muhammad Zeeshan Aslam, Mostafa Ahmed Abdellah Ahmed, Ammar Ahmed, Sidra Javaid, Ehsan Ul Haq   +6 more
doaj   +1 more source

Asthma remodeling: The pathogenic role of matrix metalloproteinase-9

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction.
Amgad A. Farhat, Ahmad S. Mohamad, Mohamad M. Shareef, Ghada Atef Attia, Manal A. Eid, Rehab W. Taha   +5 more
doaj   +1 more source

Matrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patients

Türk Biyokimya Dergisi, 2023
Schizophrenia is a neuropsychiatric disease caused by disorders in brain development due to genetic and environmental factors. The interactions and mechanisms of the two main etiological factors are not fully understood despite neurobiological, clinical ...
Karaaslan Ezgi, Kartalci Şükrü, Bağ Harika Gözde Gözükara, Acar Ceren   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Ras, metastasis, and matrix metalloproteinase 9

, 2001
Publisher Summary This chapter describes the Ras, metastasis, and matrix metalloproteinase 9. The process of metastasis involves breakdown and penetration of intercellular matrix and basement membranes. The basement membrane in particular is a barrier to tumor invasion, intravasation, and extravasation.
Bernhard, E, Muschel, R
openaire   +3 more sources

The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis [PDF]

The Journal of Immunology, 2002
Abstract Matrix metalloproteinases (MMPs) are a large group of enzymes responsible for matrix degradation. Among them, the family of gelatinases (MMP-2/gelatinase A and MMP-9/gelatinase B) is overproduced in the joints of patients with rheumatoid arthritis.
Takeshi, Itoh, Hidetoshi, Matsuda, Masatoshi, Tanioka, Kenji, Kuwabara, Shigeyoshi, Itohara, Ryuji, Suzuki   +5 more
openaire   +2 more sources