Results 261 to 270 of about 127,081 (303)
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New Heteroarylbenzenesulfonamides as Matrix Metalloproteinase Inhibitors.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Frédéric, Delbecq +4 more
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
Seminars in Oncology, 2002Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
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Metalloproteinases and their inhibitors in matrix remodeling
Trends in Genetics, 1990The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions.
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Inhibitors of Matrix Metalloproteinases
2002Matrix metalloproteinases are a family of closely related enzymes that degrade extracellular-matrix proteins. All members of the family contain a zinc-binding catalytic domain and are active at neutral pH. A generic domain structure is shown in Fig. 1.
Peter D Brown +1 more
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Structural Basis of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
Molecular Biotechnology, 2003The matrix metalloproteinases (MMPs) constitute a family of secreted/cell-surface-anchored multidomain zinc endopeptidases, all of which exhibit a catalytic domain of a common metzincin-like topology, and which are involved in degradation of the extracellular matrix but also in a number of other biologic processes. Normally, the proteolytic activity of
Maskos, K., Bode, W.
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Biological Chemistry, 2003
The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological processes. Under healthy conditions, their proteolytic activity is precisely regulated by their main endogenous ...
Bode, W., Maskos, K.
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The matrix metalloproteinases (MMPs) constitute a family of multidomain zinc endopeptidases with a metzincin-like catalytic domain, which are involved in extracellular matrix degradation but also in a number of other important biological processes. Under healthy conditions, their proteolytic activity is precisely regulated by their main endogenous ...
Bode, W., Maskos, K.
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Journal of Andrology, 2002
ABSTRACTThe matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade protein components of the extracellular matrix. The necessity of breakdown of physical barriers in the fertilization process suggests that MMPs, along with their tissue inhibitors (TIMPs), might be involved in this task.
Orit, Buchman-Shaked +3 more
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ABSTRACTThe matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade protein components of the extracellular matrix. The necessity of breakdown of physical barriers in the fertilization process suggests that MMPs, along with their tissue inhibitors (TIMPs), might be involved in this task.
Orit, Buchman-Shaked +3 more
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function
Reviews of Reproduction, 1998Growth and ovulation of follicles, and development, maintenance, and regression of the corpus luteum depend on cyclical remodelling of the extracellular matrix. The extracellular matrix consists of proteinaceous and non-proteinaceous components and provides the tissue-specific, extracellular architecture to which cells attach, and modulates the ...
E W, McIntush, M F, Smith
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The Regulation of Neovascularization by Matrix Metalloproteinases and Their Inhibitors
STEM CELLS, 1997The process of new capillary formation from preexisting vessels, angiogenesis, is a complex physiological event which is strictly controlled, occurring only very rarely under normal conditions. In contrast, there are a number of serious diseases, among them solid tumor growth, rheumatoid arthritis and several eye diseases, which are characterized by ...
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Inhibitors of matrix metallaproteinases
2016The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat ...
Ikejiri, Masahiro +4 more
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