Results 251 to 260 of about 127,081 (303)

The Matrix Metalloproteinases and Their Inhibitors

American Journal of Respiratory Cell and Molecular Biology, 1992
Abstract A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have been ...
G, Murphy, A J, Docherty
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Matrix metalloproteinase inhibitors

Current Oncology Reports, 2004
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
Nithya, Ramnath, Patrick J, Creaven
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Matrix Metalloproteinase Inhibitors

BioDrugs, 1998
The matrix metalloproteinases (MMPs) are a family of closely related, zinc-dependent proteolytic enzymes. Collectively, they are capable of degrading all the components of the extracellular matrix and as such are involved in a number of physiological and pathological processes.
S A, Watson, G, Tierney
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Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease

2021
Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov, Marta, Kalousová, Tomáš, Zima, Vladimír, Tesař   +3 more
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Matrix metalloproteinases and inhibitors in dentistry

Clinical Oral Investigations, 2019
Matrix metalloproteinase (MMP) expression has been associated with tissue development, invasive cancer cell behavior, and inflammation. The associations of increased expression of MMPs with diseases have led to intensive research activities to develop MMP inhibitors.
Gerd-Jan Boelen, Lucas Boute, Joëy d’Hoop, Mostafa EzEldeen, Ivo Lambrichts, Ghislain Opdenakker   +5 more
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Fluorinated Inhibitors of Matrix Metalloproteinases

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Viani F, Bruché L, Candiani G, Huguenot F, Jagodzinska M, Maffezzoni R, Moussier N, Sani M, Sinisi R, Zanda M   +9 more
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Matrix Metalloproteinases and Their Inhibitors

2001
Matrix metalloproteinases (MMPs) are a group of 16 enzymes that are capable of degrading extracellular matrix components. Their catalytic function is dependent on a zinc ion in the active center. MMPs are separated in three groups: gelatinases (type IV-collagenases), stromelysins, and interstitial collagenases.
A, Kugler, P, Thelen, R H, Ringert
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Matrix metalloproteinases and metalloproteinase inhibitors in human interphotoreceptor matrix and vitreous

Current Eye Research, 1998
We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous.IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMPs and TIMPs.
J J, Plantner, A, Smine, T A, Quinn
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury☆

Human Pathology, 2006
The objective of this study was to assess matrix metalloproteinase (MMP) and MMP inhibitor expression in the airspace of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) and to determine the prognostic significance of MMP expression in this patient population.
Suzanne E G, Fligiel, Theodore, Standiford, Helene M, Fligiel, Donald, Tashkin, Robert M, Strieter, Roscoe L, Warner, Kent J, Johnson, James, Varani   +7 more
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Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

Critical Reviews™ in Eukaryotic Gene Expression, 1997
Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a range of pathologies. The proteins known as the tissue inhibitors of matrix metalloproteinases (TIMPs) act to limit the enzymatic function of the MMPs. MMPs and TIMPs can be divided into two groups
P, Borden, R A, Heller
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